Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Validity and prognostic value of a novel intraoperative assessment tool for reduction in trimalleolar fractures: the SGSC checklist approach.

Archives of orthopaedic and trauma surgery·2026
Same author

Microbiota‑derived indole‑3‑propionic acid reprograms bone marrow stem cell fate via PPARγ suppression to rescue osteoporosis.

International journal of molecular medicine·2026
Same author

Urolithin A supplementation alleviates osteogenic disfunction and promotes bone fracture healing in inflammatory environments.

Food & nutrition research·2026
Same author

Inflammatory Cytokines and Sarcopenia: Evidence from Mendelian Randomization and Meta-analysis.

Current medicinal chemistry·2026
Same author

Reliability and reproducibility of the STAB classification compared with Neer and AO classifications for proximal humerus fracture-dislocations: a retrospective cohort study of 57 patients.

BMC surgery·2026
Same author

A composite hydrogel enables the spatiotemporal delivery of distinct cytokines to drive the native vascularized bone regeneration.

Bioactive materials·2026

Related Experiment Video

Updated: May 9, 2025

Electrospun Nanofiber Scaffolds with Gradations in Fiber Organization
09:32

Electrospun Nanofiber Scaffolds with Gradations in Fiber Organization

Published on: April 19, 2015

9.8K

Polydopamine-functionalized acellular fish scale scaffolds for accelerated bone tissue regeneration.

Shilong Su1,2, Ruideng Wang1,2, Jinwu Bai1,2

  • 1Department of Orthopedics, Peking University Third Hospital No. 49 North Garden Road, Haidian Beijing 100191 China.

RSC Advances
|May 1, 2025
PubMed
Summary

This study developed a polydopamine-functionalized fish scale scaffold to treat bone defects. The novel scaffold effectively reduced oxidative stress and inflammation, promoting bone regeneration.

More Related Videos

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
09:35

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Published on: September 11, 2015

9.7K
Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs
10:19

Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs

Published on: August 8, 2022

1.8K

Related Experiment Videos

Last Updated: May 9, 2025

Electrospun Nanofiber Scaffolds with Gradations in Fiber Organization
09:32

Electrospun Nanofiber Scaffolds with Gradations in Fiber Organization

Published on: April 19, 2015

9.8K
Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
09:35

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Published on: September 11, 2015

9.7K
Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs
10:19

Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs

Published on: August 8, 2022

1.8K

Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Tissue Engineering

Background:

  • Bone defects present challenges in treatment due to microenvironment changes like increased reactive oxygen species (ROS) and inflammation.
  • There is a need for bioactive materials to modulate the bone defect microenvironment and enhance bone regeneration.

Purpose of the Study:

  • To design and evaluate a novel polydopamine-functionalized acellular fish scale scaffold (PDA-AFS) for bone tissue engineering.
  • To assess the scaffold's ability to regulate the microenvironment and promote bone regeneration.

Main Methods:

  • Fabrication of PDA-AFS scaffolds from fish scales.
  • Evaluation of scaffold properties: mechanical, topographical, and biodegradability.
  • In vitro assessment of biocompatibility, cell adhesion, ROS scavenging, and immunomodulatory effects.
  • In vivo study in critical-sized calvarial bone defects to evaluate bone regeneration.
  • Transcriptome analysis to elucidate the osteogenic mechanism.

Main Results:

  • PDA-AFS exhibited excellent mechanical properties, a 3D surface topography, and biodegradability.
  • In vitro studies confirmed good biocompatibility, cell adhesion, effective ROS reduction, and immunomodulatory activity.
  • In vivo results demonstrated enhanced osteogenic differentiation of bone marrow mesenchymal stem cells and promoted endogenous bone regeneration in critical-sized defects.

Conclusions:

  • PDA-AFS serves as a promising biomaterial for bone tissue engineering scaffolds.
  • This fish scale-based scaffold offers a new strategy for treating bone defects by modulating the microenvironment and promoting regeneration.