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Updated: May 9, 2025

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
How to Assess Pulmonary Circulation and Right Heart Chambers in Systemic Sclerosis Patients?
Michele Correale1, Ester Maria Lucia Bevere2, Lucia Tricarico2
1Cardiothoracic Department, Ospedali Riuniti University Hospital, 71100 Foggia, Italy.
Abstract:
Systemic sclerosis (SSc) is a rare autoimmune connective tissue disease characterized by a widespread accumulation of extracellular matrix components leading to fibrosis of the skin and internal organs. Vascular changes occur in all involved tissues and are responsible for several distinctive clinical manifestations of the disease. This review focuses on the usefulness of various diagnostic tools in clinical practice for the early identification of clinical, functional, and/or structural RV impairment in SSc patients at risk of PH. It aims to identify specific causes of RV dysfunction, describe potential differences in outcome measures, and, ultimately, determine different cut-off values compared to subjects with PH not related to SSc.
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