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Real-world clinical experience with Obsidio Conformable Embolic.

Osman Ahmed1, John Karageorgiou2, Abhishek Kumar3

  • 1Department of Radiology, University of Chicago Medical Center, Chicago, IL, USA.

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|May 1, 2025
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Summary

Obsidio Conformable Embolic achieved 100% technical success in 131 embolization procedures for hemorrhage and tumors. This hydrogel is effective alone or with other embolic devices.

Keywords:
BleedingConformable embolicEmbolizationHemorrhageTumor

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Area of Science:

  • Interventional Radiology
  • Vascular Surgery
  • Medical Devices

Background:

  • Obsidio Conformable Embolic is a hydrogel with shear-thinning properties for vascular occlusion.
  • It is used for hemorrhage control and embolization of hypervascular tumors.
  • Clinical experience with Obsidio is limited, necessitating a field assessment survey.

Purpose of the Study:

  • To collect data on the clinical utility and procedural details of Obsidio from multiple users.
  • To evaluate the technical success of embolization procedures using Obsidio.

Main Methods:

  • A multi-institutional field survey collected data from 131 embolization procedures using Obsidio.
  • Procedures were performed between May and November 2023 across 27 US institutions.
  • Data included embolization site, vessel size, and adjunctive embolic use. Technical success was defined as complete target vasculature embolization confirmed by angiography.

Main Results:

  • 69% of procedures were for hemorrhage control, 15% for hypervascular tumors, and 17% for other indications.
  • The gastroduodenal artery was the most common embolization site (15%).
  • Obsidio was used alone in 75% of cases and combined with other devices in 25%. Technical success was 100% (131/131 procedures).

Conclusions:

  • Obsidio Conformable Embolic demonstrated successful embolization for end-organ bleeds and hypervascular tumors.
  • It is an effective embolic agent, usable independently or in combination with other devices.
  • The study supports Obsidio's utility in clinical practice for embolization procedures.