Related Experiment Videos
Familial lichen planus. More frequent than previously suggested?
Journal of the American Academy of Dermatology
|July 1, 1985
Summary
This study found a higher incidence of familial lichen planus, suggesting a significant genetic component. Familial cases appear more severe, affecting younger individuals and tending to relapse.
Area of Science:
- Dermatology
- Genetics
- Epidemiology
Background:
- Lichen planus is an inflammatory condition affecting skin and mucous membranes.
- Previous studies suggested a limited role for genetic factors in lichen planus etiology.
- Familial aggregation of lichen planus has been inconsistently reported.
Purpose of the Study:
- To investigate the prevalence of familial lichen planus.
- To compare clinical characteristics of familial versus non-familial lichen planus.
- To evaluate the role of genetic factors in lichen planus.
Main Methods:
- Follow-up study of 140 patients diagnosed with lichen planus.
- Clinical and histological verification of family history for lichen planus.
- Comparison of disease presentation and course between familial and non-familial cases.
Main Results:
- Fifteen patients (10.7%) had a verified family history of lichen planus, a higher rate than previously reported.
- Familial lichen planus presented differently, notably affecting younger individuals.
- Familial cases were more widespread and showed a greater tendency for relapse.
Conclusions:
- The high incidence of familial lichen planus supports the hypothesis of significant genetic factors in its etiology.
- Genetic predisposition may influence disease severity, age of onset, and clinical course.
- Improved detection methods may explain the higher familial rate observed in this study.