Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

8.4K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.4K
Types of RNA01:20

Types of RNA

5.5K
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
5.5K
Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

29
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
29
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

353
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
353
Alternative RNA Splicing02:18

Alternative RNA Splicing

20.9K
Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
20.9K
RNA Splicing01:32

RNA Splicing

55.9K
Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
55.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparing cognitive orientation to daily occupational performance and motivational interviewing in stroke rehabilitation: A protocol for a randomized controlled trial.

The British journal of occupational therapy·2026
Same author

Enhancing cisplatin chemosensitivity in gastric cancer through LINC00162 silencing: Modulation of the PI3K/AKT pathway and NANOG downregulation.

BioImpacts : BI·2026
Same author

Nutraceuticals: A strategy to mitigate neurotoxicity.

Advances in neurotoxicology·2026
Same author

Mechanistic insight into visible light photocatalytic removal of meropenem from wastewater utilizing nickel based LDH nanostructures with synergistic adsorption effects.

Scientific reports·2026
Same author

Interface-Induced Concentration Enhancement in Glycine Solutions Investigated Using Surface Plasmon Resonance Spectroscopy and Molecular Dynamics Simulations.

The journal of physical chemistry letters·2026
Same author

Robotic rehabilitation and intelligent algorithms improving the performance skills of stroke patients: a scoping review.

Journal of bodywork and movement therapies·2026

Related Experiment Video

Updated: May 23, 2025

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
09:36

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

Published on: April 10, 2018

25.2K

Long non-coding RNAs in schizophrenia.

Seyyed Navid Mousavinejad1, Seyed Ali Hosseini2, Mozhdeh Mohammadpour3

  • 1Department of Clinical Biochemistry, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|May 1, 2025
PubMed
Summary

Long noncoding RNAs (lncRNAs) are key players in schizophrenia, affecting gene expression and neurodevelopment. Altered lncRNA levels in patients suggest their potential as diagnostic biomarkers for this complex brain disorder.

Keywords:
BiomarkersNeurodevelopmental processesSchizophrenialncRNAs

More Related Videos

Chromatin Isolation by RNA Purification ChIRP
11:09

Chromatin Isolation by RNA Purification ChIRP

Published on: March 25, 2012

86.1K
CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis
10:40

CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis

Published on: April 25, 2022

2.3K

Related Experiment Videos

Last Updated: May 23, 2025

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
09:36

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

Published on: April 10, 2018

25.2K
Chromatin Isolation by RNA Purification ChIRP
11:09

Chromatin Isolation by RNA Purification ChIRP

Published on: March 25, 2012

86.1K
CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis
10:40

CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis

Published on: April 25, 2022

2.3K

Area of Science:

  • Neuroscience
  • Genetics
  • Molecular Biology

Background:

  • Schizophrenia is a complex neuropsychiatric disorder with genetic and environmental influences.
  • Long noncoding RNAs (lncRNAs) are increasingly recognized as critical regulators in disease pathogenesis.
  • Aberrant lncRNA expression is observed in schizophrenia patients' blood and brain tissues.

Purpose of the Study:

  • To review the current understanding of lncRNAs' role in schizophrenia.
  • To highlight the diagnostic potential of lncRNAs in schizophrenia.
  • To explore lncRNAs as potential therapeutic targets.

Main Methods:

  • Literature review of studies on lncRNAs and schizophrenia.
  • Analysis of lncRNA expression profiles in patient samples.
  • Investigation of lncRNA mechanisms in neurobiological pathways.

Main Results:

  • Specific lncRNAs (Gomafu, DISC-2, BDNF-AS, MEG3, TUG1) are dysregulated in schizophrenia.
  • lncRNAs influence neurodevelopment, inflammation, and synaptic plasticity.
  • Antipsychotic treatment affects lncRNA expression, correlating with symptom improvement.
  • Sex-specific and age-related differences in lncRNA regulation are noted.

Conclusions:

  • lncRNAs are significantly implicated in schizophrenia pathophysiology.
  • Altered lncRNA expression holds promise as a diagnostic biomarker.
  • lncRNAs represent potential targets for novel therapeutic strategies in schizophrenia.