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Case Report: Exploring delayed hyperprogressive disease: a case study of post-immunotherapy in lung cancer
Jie Zhou1, Kexin Cao2, Jin-Xia Wei3
1Department of Respiratory Oncology, Renmin Hospital of Qingxian, Cangzhou, China.
Frontiers in Immunology
|May 2, 2025
Summary
Hyperprogressive disease (HPD) can occur later than two months after immunotherapy. This case study presents HPD occurring after five months, successfully treated with chemoembolization.
Area of Science:
- Oncology
- Immunotherapy
- Cancer Progression
Background:
- Immunotherapy improves survival in advanced cancers but can cause hyperprogressive disease (HPD).
- HPD is typically defined as occurring within two months of immunotherapy initiation.
- The association between HPD and immunotherapy beyond two months remains unclear.
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