Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Trophoblastic-Differentiated Urothelial Carcinoma: Real-World Sequencing and Clinical Implications.

Clinical genitourinary cancer·2026
Same author

External Validation of the International Bladder Cancer Group Intermediate-risk Non-muscle-invasive Bladder Cancer Substratification Model.

European urology oncology·2026
Same author

Epidemiological Trends and Germline Variant Analysis of Young-Onset Bladder Cancer.

Clinical genitourinary cancer·2026
Same author

Editorial Comment.

The Journal of urology·2026
Same author

Re-Evaluating the Role of Locoregional Therapy in Metastatic Prostate Cancer: A Review of Current Evidence and Evolving Clinical Approaches.

The Urologic clinics of North America·2026
Same author

Machine learning approaches to optimize the integration of sociodemographic factors for predicting cancer-specific survival among patients with high-risk prostate cancer.

Current urology·2026
Same journal

Role and relevance of genetic testing in patients with kidney stones: a review from EAU Section of Endourology.

Current opinion in urology·2026
Same journal

Advances in evaluating and delivering nontechnical skills training: The use of simulation, robotics, artificial intelligence and virtual reality.

Current opinion in urology·2026
Same journal

Educating for a sustainable future: faculty and student perspectives and a review of environmental sustainability in medical education - an EAU endourology study.

Current opinion in urology·2026
Same journal

Shaping the future of endourology: role of education, simulation and uro-technology: a scoping review by the EAU Section of Endourology.

Current opinion in urology·2026
Same journal

A review of emerging technologies and techniques for percutaneous nephrolithotomy access.

Current opinion in urology·2026
Same journal

Artificial intelligence in kidney cancer: a review of clinical applications across the disease spectrum.

Current opinion in urology·2026
See all related articles

Related Experiment Video

Updated: May 9, 2025

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer
13:19

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer

Published on: November 2, 2013

16.5K

Tissue-based gene expression testing in localized prostate cancer.

Nethusan Sivanesan1, Gabriela M Diaz, Preston C Sprenkle

  • 1Yale School of Medicine, Department of Urology, New Haven, Connecticut, USA.

Current Opinion in Urology
|May 2, 2025
PubMed
Summary
This summary is machine-generated.

Tissue-based genomic tests improve prostate cancer (PCa) risk assessment beyond traditional markers. These assays aid treatment decisions, reducing overtreatment for low-risk patients and guiding intervention for high-risk individuals.

Keywords:
gene expressiongenomic classifierprostate cancerrisk stratification

More Related Videos

miRNA Expression Analyses in Prostate Cancer Clinical Tissues
11:29

miRNA Expression Analyses in Prostate Cancer Clinical Tissues

Published on: September 8, 2015

10.8K
Preparation of Formalin-fixed Paraffin-embedded Tissue Cores for both RNA and DNA Extraction
08:30

Preparation of Formalin-fixed Paraffin-embedded Tissue Cores for both RNA and DNA Extraction

Published on: August 21, 2016

50.8K

Related Experiment Videos

Last Updated: May 9, 2025

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer
13:19

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer

Published on: November 2, 2013

16.5K
miRNA Expression Analyses in Prostate Cancer Clinical Tissues
11:29

miRNA Expression Analyses in Prostate Cancer Clinical Tissues

Published on: September 8, 2015

10.8K
Preparation of Formalin-fixed Paraffin-embedded Tissue Cores for both RNA and DNA Extraction
08:30

Preparation of Formalin-fixed Paraffin-embedded Tissue Cores for both RNA and DNA Extraction

Published on: August 21, 2016

50.8K

Area of Science:

  • Oncology
  • Genomics
  • Molecular Diagnostics

Background:

  • Localized prostate cancer (PCa) management benefits from personalized risk stratification.
  • Traditional markers (PSA, Gleason score) have limitations due to tumor heterogeneity.
  • Genomic assays offer enhanced prognostic capabilities for PCa.

Purpose of the Study:

  • Review current tissue-based genomic testing in localized PCa.
  • Explore genomic assays, clinical applications, challenges, and future directions.
  • Evaluate the role of genomic testing in PCa risk stratification and treatment decisions.

Main Methods:

  • Literature review of recent research on genomic assays for localized PCa.
  • Analysis of commonly used genomic tests: Decipher, Oncotype DX (GPS), and Prolaris.
  • Evaluation of clinical evidence supporting prognostic capabilities and treatment guidance.

Main Results:

  • Genomic assays provide personalized risk stratification beyond traditional markers.
  • Decipher shows established prognostic value; Prolaris and GPS require further validation.
  • Genomic testing guides therapeutic choices, potentially reducing overtreatment and optimizing intervention.

Conclusions:

  • Tissue-based genomic tests are emerging as valuable prognostic tools in PCa.
  • Clinical adoption is growing, but challenges like cost and access persist.
  • Further prospective studies are needed to optimize implementation and validate long-term impact.