Ligand-Enabled Palladium-Catalyzed β-C(sp3)-H Biarylation of Native Amides with Cyclic Diaryliodonium Salts
Animesh Das1, Mohit Chotia1, Biplab Maji1
1Department of Chemical Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur 741246, India.
Abstract:
Herein, we report a Pd-catalyzed β-C(sp3)-H biarylation of native amides using diaryliodonium salts. A pyridine-3-sulfonic acid ligand that might stabilize the substrate-bound palladium species was found to be essential for high catalytic activity. The reaction displayed a broad scope and showed excellent compatibility with diverse cyclic diaryliodonium salts and amide substrates. The retained iodo functionality on the product provides a versatile handle for further increasing molecular complexity.
More Related Videos
Related Concept Videos
Reduction of Alkenes: Asymmetric Catalytic Hydrogenation
The metal catalyst used can be either heterogeneous or homogeneous. When hydrogenation of an alkene generates a chiral center, a pair of enantiomeric products is expected to form. However, an enantiomeric excess of one of the products can be facilitated using an enantioselective reaction or an...
Metal-Ligand Bonds
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
[4+2] Cycloaddition of Conjugated Dienes: Diels–Alder Reaction
Cationic Chain-Growth Polymerization: Mechanism
Diels–Alder Reaction Forming Bridged Bicyclic Products: Stereochemistry
α-Bromination of Carboxylic Acids: Hell–Volhard–Zelinski Reaction
![Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-phosphinetriyltripiperidine]}palladium Under Mild Reaction Conditions](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F51444.jpg&w=3840&q=50)

