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Related Experiment Video

Updated: May 7, 2026

Evaluation of a Universal Nested Reverse Transcription Polymerase Chain Reaction for the Detection of Lyssaviruses

Evaluation of a Universal Nested Reverse Transcription Polymerase Chain Reaction for the Detection of Lyssaviruses

Published on: May 2, 2019

Rabies Virus Targeting NIR-II Phototheranostics.

Qihang Ding¹, Caiqian Wang², Haoran Wang²

¹Department of Chemistry, Korea University, Seoul 02841, Korea.

Journal of the American Chemical Society

|May 2, 2025

Summary

Researchers developed a novel nanotheranostic probe for rabies. This probe targets the rabies virus (RABV), enables imaging, and provides photodynamic therapy (PDT) for potential clinical use.

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Area of Science:

Biomedical Engineering
Nanotechnology
Infectious Diseases

Background:

Rabies is a fatal viral disease with no effective treatments.
Current diagnostic and therapeutic strategies for rabies are limited.
The blood-brain barrier (BBB) presents a significant challenge for treating central nervous system infections.

Purpose of the Study:

To develop a novel nanotheranostic probe for rabies diagnosis and therapy.
To create a probe capable of crossing the blood-brain barrier (BBB).
To enable precise targeting of the rabies virus (RABV) and facilitate photodynamic therapy (PDT).

Main Methods:

Synthesis of a novel NIR-II organic polyacetylene fluorophore (DK).
Self-assembly of DK with a biocompatible, BBB-permeable nanoparticle carrier (N3-PEG2000-R).
Modification of the probe surface with an aptamer targeting RABV glycoprotein (RVG) to create DK@RA-PEG.

Main Results:

The nanotheranostic probe (DK@RA-PEG) effectively crossed the BBB in mice.
Real-time NIR-II fluorescence imaging visualized probe localization at the infection site.
The probe demonstrated safe and effective photodynamic therapy (PDT) by converting light to chemical energy without thermal effects.

Conclusions:

The developed nanotheranostic probe integrates targeting, imaging, and therapy for rabies.
DK@RA-PEG shows promise for clinical applications in rabies treatment.
This theranostic approach offers a potential solution for overcoming the limitations of current rabies interventions.