Related Experiment Video
Updated: May 3, 2026

11:58
Primary Culture of Mouse Dopaminergic Neurons
Published on: September 8, 2014
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Dopaminergic neurons entering the brain under the immunological cover of darkness
Timothy Chai1, Julie Y Chen1, Kyle M Loh1
1Department of Developmental Biology, Institute for Stem Cell Biology & Regenerative Medicine, Stanford University, Stanford, CA 94305, USA.
Cell Stem Cell
|May 2, 2025
Abstract:
The ability to transplant immunologically foreign cells into an animal without immune suppression would be transformative. Pavan et al. show that human pluripotent stem cell-derived dopaminergic neuron progenitors engineered to express eight immune-evasive proteins can engraft in humanized mice and a rat model of Parkinson's disease without recourse to immune suppression.1.
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