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TAMing immunity through an unexpected source
1Institute for Research in Biomedicine (IRB), Università della Svizzera italiana, Bellinzona, Switzerland.
Abstract:
Arginine availability and metabolism critically shape tumor-immune interactions. In this issue of Cancer Cell, Zhu et al. demonstrate that breast cancer-cell-derived arginine synthesized via ASS1 fuels macrophage polyamine synthesis, reinforcing immunosuppressive tumor-associated macrophages (TAMs). Mechanistically, this occurs through TDG/p53-dependent DNA demethylation and activation of PPARG.
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