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Alzheimer's Disease: Treatment

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Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...

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Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

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A Non-Randomized Pilot Trial of Brain-WISE: A Group-Based Program for Brain Health and Dementia Risk Reduction in

Matthew L Cohen^1,2, Kimberly Van Buren¹, Mindy J Myers¹

¹Department of Communication Sciences and Disorders, University of Delaware, Newark, DE, USA.

Journal of Geriatric Psychiatry and Neurology

|May 3, 2025

Summary

The Brain-WISE program, designed to boost brain health, showed high participant engagement and improved knowledge and motivation in older adults. Further research is recommended for this community-based intervention.

Keywords:

Alzheimer’s disease dementia dementia prevention lifestyle non-pharmacological intervention risk reduction behavior

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Area of Science:

Gerontology
Public Health
Cognitive Science

Background:

Dementia is a significant public health concern, with up to 45% of cases potentially preventable by addressing modifiable risk factors.
Community-based interventions are crucial for promoting brain health and cognitive function in aging populations.

Purpose of the Study:

To develop and pilot test the Brain-WISE intervention, a low-intensity, group-based program aimed at enhancing brain health in community settings.
To assess the acceptability, adherence, and preliminary effects of the Brain-WISE program on participants' knowledge and motivation.

Main Methods:

A non-randomized pilot trial involving 143 community-dwelling adults aged 56-93.
A 6-session intervention incorporating psychoeducation, group discussions, activities, and health screenings.
Assessment of adherence via attendance rates and acceptability through questionnaires; evaluation of brain health knowledge and motivation pre- and post-intervention.

Main Results:

High adherence rates (80%-97% attendance) and program acceptability (96% agreement that it was worthwhile).
Significant improvements in brain health knowledge (d = 0.83, P < .001) and motivation to improve brain health (d = 0.43, P < .001).

Conclusions:

The Brain-WISE program demonstrated good adherence and acceptability among older adults.
Preliminary evidence suggests the intervention positively impacts brain health knowledge and motivation, warranting further investigation.