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A Comprehensive Procedure to Evaluate the In Vivo Performance of Cancer Nanomedicines

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Published on: March 4, 2017

Next-Generation Transformable Nanomedicines: Revolutionizing Cancer Drug Delivery and Theranostics.

Swapnil Shinde¹, Saurabh Shah¹, Paras Famta¹

¹Pharmaceutical Innovation and Translational Research Lab (PITRL), Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad 500037, India.

Molecular Pharmaceutics

|May 3, 2025

Summary

Transformable nanomedicine uses tunable nanocarrier properties to improve cancer treatment. This review explores strategies for enhanced drug delivery, overcoming challenges in targeting the tumor microenvironment (TME) for better outcomes.

Keywords:

Cellular uptake Protein corona Stimuli-responsive nanoparticles Transformable nanocarriers Tumor penetration strategies

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Published on: March 25, 2019

Area of Science:

Nanomedicine
Biomedical Engineering
Oncology

Background:

Conventional cancer therapies face challenges like poor circulation and inefficient tumor targeting.
Nanomedicine offers solutions by optimizing nanocarrier properties for drug delivery.
Existing nanocarriers struggle with short circulation times and immune system sequestration.

Purpose of the Study:

To review transformable nanomedicine strategies for cancer therapy.
To explore how modulating nanocarrier properties (charge, morphology, surface chemistry) enhances drug delivery.
To analyze the impact of tunable characteristics on pharmacokinetics, biodistribution, and tumor microenvironment (TME) targeting.

Main Methods:

Review of current literature on transformable nanomedicine.
Analysis of physicochemical property modulation in nanocarriers.
Investigation of internal and external stimuli-activated strategies.
Evaluation of impact on pharmacokinetics and TME targeting.

Main Results:

Modulating nanocarrier geometry, charge, and hydrophilicity can mitigate delivery barriers.
Transformable strategies show potential for improved circulation and TME accumulation.
Tunable properties influence drug release kinetics and targeted delivery efficiency.

Conclusions:

Controlled modulation of nanocarrier properties is key for advanced anticancer nanomedicine.
Transformable nanomedicine offers promising strategies to overcome current therapeutic limitations.
Addressing clinical translation challenges is crucial for the feasibility of nanomedicine-based cancer therapies.