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Related Experiment Video

Updated: May 9, 2025

Intubation, Central Venous Catheter, and Arterial Line Placement in Swine for Translational Research in Abdominal Transplantation Surgery

Intubation, Central Venous Catheter, and Arterial Line Placement in Swine for Translational Research in Abdominal Transplantation Surgery

Published on: February 3, 2023

Pig Models in Translational Surgery.

Rebecca Goutchtat^1,2, Axelle Béguier^3,4, Nathalie Kasal-Hoc⁵

¹IMRB, Inserm, Université Paris Est Créteil, Créteil, France.

European Surgical Research. Europaische Chirurgische Forschung. Recherches Chirurgicales Europeennes

|May 4, 2025

Summary

This summary is machine-generated.

The pig model is crucial for surgical research due to anatomical similarities with humans, advancing fields like cardiovascular and digestive surgery. Future research will focus on xenotransplantation and ethical considerations.

Keywords:

Cardiothoracic surgery Gastro-intestinal surgery Pig model Surgical research Xenotransplantation

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Area of Science:

Biomedical Engineering
Translational Surgery
Comparative Anatomy

Background:

Rodent models are limited for human surgical translation due to size constraints.
Pigs offer significant translational value in surgical research owing to anatomical and physiological similarities with humans.

Purpose of the Study:

To review the diverse applications and future potential of the pig model in various surgical research fields.
To highlight the pig's role in advancing cardiovascular, digestive, endocrine, osteoarticular, and neurosurgery.
To discuss the implications of pig-to-human xenotransplantation and ethical considerations.

Main Methods:

Literature review of studies utilizing the pig model in surgical research.
Analysis of pig model contributions across different surgical specialties.
Examination of current and future trends, including xenotransplantation and robotic surgery.

Main Results:

Pigs have been instrumental in developing stents, improving bypass grafting, and advancing heart valve xenotransplantation.
The pig model aids in mesh development for abdominal repair, liver regeneration studies, and metabolic surgery research.
Increasing use in osteoarticular and neurosurgery, and crucial for testing surgical equipment, minimally invasive techniques, and robotic surgery training.

Conclusions:

The pig model has significantly contributed to surgical research advancements, particularly in xenotransplantation.
Future research will focus on refining pig models for enhanced preclinical reliability and addressing ethical concerns.
Pig-to-human xenotransplantation shows promise but requires further research for long-term safety and efficacy.