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Updated: Jul 8, 2026

Technique of Subnormothermic Ex Vivo Liver Perfusion for the Storage, Assessment, and Repair of Marginal Liver Grafts

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Revolution in Organ Preservation: Technological Exploration.

Xin-Yuan Kang¹, Jia-Yi Cheng¹, Wan-Yi Ge¹

¹Key Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi'an 710129, Shaanxi, PR China.

Acta Biomaterialia

|May 4, 2025

Summary

Advancements in organ preservation, from hypothermic storage to supercooling and vitrification, are crucial for overcoming donor shortages and ischemia-reperfusion injury (IRI). Technological innovation is key to extending organ viability and improving transplant outcomes.

Keywords:

Cryopreservation Ice crystal formation Organ preservation Organ transplantation low-temperature preservation technique

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Area of Science:

Transplantation Medicine
Biotechnology
Organ Preservation Science

Background:

Organ preservation is vital for addressing donor shortages and ischemia-reperfusion injury (IRI) in transplantation.
Continuous innovation in preservation technologies is necessary to meet the growing demand for transplantable organs.

Purpose of the Study:

To provide a comprehensive review of organ preservation techniques, from historical methods to emerging technologies.
To analyze the mechanisms underlying different preservation strategies and their impact on organ quality and viability.

Main Methods:

Review of historical milestones in organ preservation solutions (e.g., EuroCollins, UW, ET-Kyoto, Celsior).
Analysis of advanced techniques including hypothermic storage, supercooling, vitrification, partial freezing, machine perfusion, and cryopreservation.
Exploration of emerging trends like nanotechnology and artificial organ cultivation.

Main Results:

Organ preservation techniques aim to suppress metabolic rates, prevent ice crystal formation, and utilize cryoprotectants to extend preservation duration.
Technological advancements are crucial for improving organ quality and addressing the global organ shortage crisis.
Emerging trends show promise for significantly enhancing preservation efficiency.

Conclusions:

Technological innovation in organ preservation is essential for improving transplantation outcomes and overcoming the global organ shortage.
The integration of novel materials and methodologies, including nanotechnology, can revolutionize organ transplantation.
This review provides insights into advancing organ preservation for more effective and sustainable organ banking.