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Published on: December 30, 2016
Dimeric citrinins diversity revealed by the deep-sea-derived Penicillium citrinum W23
Tai-Zong Wu1, Zhi-Hui He2, Cheng-You Lin2
1Hainan Academy of Medical Sciences, Hainan Medical University, 3 Xueyuan Road, Haikou, 571199, China; Key Laboratory of Marine Genetic Resources, Third Institute of Oceanography, Ministry of Natural Resources, 184 Daxue Road, Xiamen, 361005, China.
Abstract:
The chemical investigation of a deep-sea-derived fungus, Penicillium citrinum W23, yielded five previously undescribed (1-5) and one known (6) dimeric citrinin derivatives. Their structures were elucidated through extensive spectroscopic analysis, DFT calculations and biogenetic considerations. Compounds 1-6 exhibited diverse connectivity patterns between the two monomeric units with 4-5 being the first exemplars of citrinin dimers featuring a C8'-O-C6-C7-C10' linkage. This study expands the diversity of citrinin derivatives and highlights the power of GIAO-based NMR calculation in distinguishing closely resembling constitutional isomers.
