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Anti-neuroinflammatory naphthol dimers from the marine-derived fungus Penicillium sp. HQ1-23
Yuan-Han Xie1, Chun-Hong Wang1, Rong Wang1
1Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Guangxi Key Laboratory of Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin, 541004, China.
Abstract:
Five undescribed naphthol dimers, penibinaphthols A-E (1-5), and two known analogues (6 and 7), were isolated from the marine-derived fungus Penicillium sp. HQ1-23. Their structures were elucidated based on spectroscopic data analysis, and the absolute configurations were determined by X-ray crystallographic data and ECD spectroscopic analysis. Compound 3, with a ketone carbonyl group at C-1', potently inhibited LPS-induced NO production in BV-2 microglial cells (IC50 = 6.86 ± 0.10 μM), surpassing that of the positive control minocycline (IC50 = 23.57 ± 0.92 μM). Moreover, compound 3 decreased LPS-induced iNOS and COX-2 expression and reduced LPS-stimulated levels of pro-inflammatory cytokines TNF-α, IL-1β, and IL-6.
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