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Empowering Healthcare with Phage Display Technology
Bingze Lyu1, Haolin Zhou1, Huijun Wang1
1Cellular Signaling Laboratory, International Research Center for Sensory Biology and Technology of MOST, Key Laboratory of Molecular Biophysics of MOE, College of Life Science and Technology, Huazhong University of Science and Technology, 430074 Wuhan, Hubei, China.
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Phage display technology, a molecular screening tool introduced in 1985, facilitates the display of peptides or proteins on phage surfaces to identify high-affinity ligands. Phage display has enabled the identification of peptides that enhance biomaterial biocompatibility, support stem cell proliferation and differentiation, and facilitate targeted drug delivery. Additionally, it has been utilized in bacterial detection, disease biomarker identification, and targeted therapies, including crossing the blood-brain barrier for improved cancer treatments. Despite challenges such as peptide stability and immunogenicity, ongoing innovations continue to enhance its therapeutic potential. This review discusses the potential of phage display technology for empowering healthcare through demonstrating its development in various biological fields in recent years.
