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Comparison of Collagen and Polylactic Acid Multifilament Yarns for Developing Textile Scaffolds for Tendon Tissue
Yihan Huang1, Robert Tonndorf2, Jessica M Gluck1
1Wilson College of Textiles, North Carolina State University, Raleigh, North Carolina, USA.
Summary
This study compared natural collagen and synthetic polylactic acid (PLA) yarns for tendon tissue engineering scaffolds. PLA yarns coated with collagen demonstrated superior mechanical properties and biocompatibility, making them a promising scaffold material.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Polymer Chemistry
Background:
- Tendon injuries require effective tissue engineering scaffolds.
- Natural and synthetic polymers are being explored for scaffold fabrication.
- Collagen and polylactic acid (PLA) offer distinct properties for biomaterial applications.
Purpose of the Study:
- To compare the mechanical properties and biocompatibility of collagen and PLA multifilament yarns.
- To evaluate their suitability for fabricating tendon tissue engineering scaffolds.
- To determine optimal crosslinking conditions for collagen yarns using genipin.
Main Methods:
- Investigated multifilament yarns made from natural collagen and synthetic PLA.
- Optimized genipin crosslinking of collagen yarns (1.0% genipin, 37°C, 72h).
- Assessed mechanical properties (tensile strength) and degradation (enzymatic study) of both yarn types.
- Evaluated cell compatibility of PLA yarns after collagen coating.
Main Results:
- Optimized genipin crosslinking enhanced collagen yarn stability.
- PLA yarns exhibited superior resistance to degradation and higher tensile strength compared to collagen yarns.
- Collagen-coated PLA yarns supported tendon cell growth and proliferation, indicating improved biocompatibility.
Conclusions:
- Genipin-crosslinked collagen yarns show potential but have limitations in mechanical strength and degradation resistance.
- Multifilament PLA yarns coated with collagen represent a promising biomaterial for tendon tissue engineering scaffolds.
- The combination of PLA's mechanical robustness and collagen's biocompatibility offers a viable solution for scaffold development.
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