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Weill-Marchesani syndrome with bilateral angle-closure glaucoma
Journal of Pediatric Ophthalmology and Strabismus
|July 1, 1985
Summary
Cyclopentolate can trigger acute glaucoma in children with Weill-Marchesani syndrome. Early diagnosis of this syndrome is crucial for managing acute glaucoma in pediatric patients.
Area of Science:
- Ophthalmology
- Genetics
Background:
- Weill-Marchesani syndrome is a rare genetic disorder characterized by short stature, brachydactyly, and distinctive facial features.
- Acute angle-closure glaucoma is an ophthalmic emergency characterized by a sudden increase in intraocular pressure.
Observation:
- A case of bilateral acute angle-closure glaucoma induced by cyclopentolate in a child with undiagnosed Weill-Marchesani syndrome.
- Initial treatment with Pilocarpine worsened the glaucoma due to induced pupillary block.
Findings:
- Cyclopentolate-induced mydriasis and cycloplegia can precipitate acute angle-closure glaucoma in patients with Weill-Marchesani syndrome, even without lens subluxation.
- This is the first reported case linking these specific conditions.
Implications:
- Highlights the importance of considering Weill-Marchesani syndrome in pediatric acute glaucoma cases.
- Suggests caution when using mydriatic and cycloplegic agents in children with suspected Weill-Marchesani syndrome.
- Emphasizes the need for prompt diagnosis of Weill-Marchesani syndrome to guide appropriate glaucoma management.