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Updated: May 17, 2025
Noninvasive Assessment of Cardiac Abnormalities in Experimental Autoimmune Myocarditis by Magnetic Resonance Microscopy Imaging in the Mouse
Published on: June 20, 2014
A Blind Spot in Imaging: Immune Checkpoint Inhibitor-Induced Myocarditis with Negative Cardiac MRI.
Lubna Alnatour1, Ayham Mahmoud2, Ameer Awashra3
1School of Medicine, University of Jordan, Amman, Jordan.
Immune checkpoint inhibitor (ICI)-induced myocarditis is a rare but serious condition. Cardiac MRI is key for diagnosis, but biopsy may be needed if imaging is inconclusive.
Area of Science:
- Cardiology
- Immunology
- Oncology
Background:
- Immune checkpoint inhibitors (ICIs) are revolutionary cancer therapies.
- Myocarditis is a rare but severe adverse effect of ICIs.
- High morbidity and mortality rates are associated with ICI-induced myocarditis.
Purpose of the Study:
- To highlight the diagnostic challenges of ICI-induced myocarditis.
- To emphasize the role of cardiac imaging and biopsy in diagnosis.
Main Methods:
- Review of current literature on ICI-induced myocarditis.
- Analysis of diagnostic pathways, including cardiac magnetic resonance imaging (CMR) and endomyocardial biopsy.
Main Results:
- Cardiac magnetic resonance imaging (CMR) is the primary non-invasive diagnostic tool.
- Endomyocardial biopsy remains essential for diagnosis in cases with negative CMR findings.
Conclusions:
- Early recognition and accurate diagnosis of ICI-induced myocarditis are critical.
- A multimodal diagnostic approach combining CMR and biopsy ensures timely management.
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