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Epigenetic Regulation

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...

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Home
Washu Epigenome Browser Update 2025.

Home
Washu Epigenome Browser Update 2025.

Related Experiment Video

A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes

A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes

Published on: May 22, 2018

WashU Epigenome Browser update 2025.

Chanrung Seng¹, Shane Liu¹, Wenjin Zhang¹

¹Department of Genetics, The Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63110, United States.

Nucleic Acids Research

|May 5, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

The WashU Epigenome Browser has been rewritten with a smaller, faster codebase, enhancing performance and user experience for exploring genomic and epigenomic data. New features include advanced visualization for methylation data and comparative genomics capabilities.

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Area of Science:

Genomics
Bioinformatics
Computational Biology

Background:

The WashU Epigenome Browser is a critical tool for visualizing and analyzing epigenomic data.
Previous versions faced challenges with the evolving JavaScript ecosystem and external library dependencies.
Enhancements were needed to improve performance, user experience, and maintainability.

Purpose of the Study:

To present a significantly updated version of the WashU Epigenome Browser with a rewritten codebase.
To improve the browser's performance, loading efficiency, and ease of installation.
To introduce new features for advanced data visualization and comparative genomics.

Main Methods:

Completely rewriting the codebase with minimized external JavaScript libraries.

Optimizing the production compilation for a smaller code bundle size.

Implementing a modular design for potential export as standalone modules.

Developing novel track types for long-read and single-cell methylation data visualization.

Creating a comparative genomics track for comparing different genome assemblies (e.g., hg38 and chm13).

Main Results:

Achieved a significantly smaller code bundle size, improving loading efficiency and overall performance.
Enhanced scripting, graphics rendering, and painting performance.
Enabled faster and more straightforward installation due to fewer external dependencies.
Introduced new visualization tracks for methylation data and comparative genomics.
Established a data hub for comparing hg38 and chm13 genome assemblies.

Conclusions:

The rewritten WashU Epigenome Browser offers superior performance and user experience.
The modular design and reduced dependencies facilitate easier maintenance and integration.
New features enhance the analysis of complex epigenomic and genomic datasets, including comparative genomics.