Related Experiment Video
Updated: Jun 16, 2025
07:43
Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of Neurodevelopmental Disorders
Published on: May 12, 2015
11.2K
Unraveling Neurodevelopment: Synergistic Effects of Intrinsic Genetic Programs and Extrinsic Environmental Cues
Yanyan Wang1,2, Shukui Zhang1,2, Huiyang Jia1,2
1State Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.
Summary
This study explores brain development, focusing on neural stem cell regulation, microglia origins, and cerebrovascular interactions. It examines epigenetic influences, immune system impacts, and inter-species differences in neurogenesis.
Area of Science:
- Neuroscience
- Developmental Biology
- Immunology
Background:
- Brain development relies on neural stem cell (NSC) proliferation and differentiation.
- Microglia and cerebrovasculature are critical for brain function and development.
- Understanding these processes is key to addressing neurodevelopmental disorders.
Purpose of the Study:
- To investigate intrinsic regulatory mechanisms of NSCs during neurogenesis.
- To explore the origin, heterogeneity, and function of microglia in development.
- To examine the cerebrovascular system's role in brain development.
Main Methods:
- Analysis of epigenetic modifications affecting NSC proliferation and differentiation.
- Investigation of maternal immune activation's impact on neurogenesis.
- Examination of microglia development and their influence on surrounding cells.
- Study of blood vessel and NSC interactions and cytokine effects.
Main Results:
- Epigenetic factors and immune activation significantly influence NSC behavior.
- Microglia exhibit developmental heterogeneity and impact neighboring cells.
- Cerebrovascular system actively communicates with NSCs and influences glial genesis.
Conclusions:
- Intrinsic and extrinsic factors intricately regulate neurogenesis and brain development.
- Microglia and vascular systems are dynamic players in establishing brain architecture.
- Comparative analysis highlights species-specific mechanisms in brain development.
Related Concept Videos
01:20Gene-Environment Interactions
270
Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...
270
01:28Human Genetics
551
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
551
02:27Background and Environment Affect Phenotype
6.5K
Although the genetic makeup of an organism plays a major role in determining the phenotype, there are also several environmental factors, such as temperature, oxygen availability, presence of mutagens, that can alter an organism’s phenotype.
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
6.5K
01:30Introduction to Biological Bases of Psychology
3.2K
Biopsychology serves as a vital bridge connecting the intricate domains of biology and psychology, shedding light on how biological systems influence psychological phenomena. This field scrutinizes the biological substrates of behavior and mental processes, emphasizing the nervous system along with the roles of neurotransmitters, hormones, and genetics. It also incorporates evolutionary perspectives to explain the adaptive nature of mental functions.
The nervous system, the cornerstone of...
The nervous system, the cornerstone of...
3.2K
01:23Behavioral Genetics and Its Designs
346
Behavior genetics explores how genetic inheritance influences human behavior. It focuses on how genes, passed from parents to offspring, contribute to the development of behavioral traits and tendencies. This branch of genetics seeks to understand the complex interplay between inherited genetic factors and environmental influences in shaping our behaviors.
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
346
01:37Epigenetic Regulation
3.0K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
X-chromosome...
3.0K