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Comparing Transperitoneal Retroperitoneal Access and Percutaneous Puncture for Lumbar Disc Degeneration Modeling in

Li Wenhan1, He Wenshan2, Lu Qunwen1

  • 1Tui-Na department, Hospital of Chengdu University of Traditional Chinese Medicine.

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Summary

The trans-retroperitoneal approach is superior for inducing intervertebral disc degeneration (IVDD) in rabbits, showing more severe degeneration and lower mortality than the percutaneous method.

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Area of Science:

  • Biomedical Engineering
  • Orthopedics
  • Animal Models

Background:

  • Intervertebral disc degeneration (IVDD) is a significant cause of low back pain.
  • Developing reliable animal models is crucial for studying IVDD.
  • Comparing induction methods ensures optimal model selection.

Purpose of the Study:

  • To compare the efficacy of percutaneous versus trans-retroperitoneal puncture for inducing IVDD in rabbits.
  • To evaluate mortality rates and degenerative changes associated with each method.
  • To identify the most suitable method for IVDD modeling.

Main Methods:

  • Fifteen New Zealand White rabbits were divided into sham, percutaneous puncture, and trans-retroperitoneal puncture groups.
  • Induction of IVDD via annulus fibrosus puncture.
  • Comprehensive assessment including mortality, morphology, histology, radiology, and biomarkers.

Main Results:

  • Both puncture methods successfully induced IVDD in the rabbit model.
  • The trans-retroperitoneal approach led to more pronounced disc degeneration.
  • The trans-retroperitoneal method demonstrated a significantly lower mortality rate.

Conclusions:

  • The trans-retroperitoneal approach is a more advantageous method for inducing IVDD in rabbits.
  • This model provides a foundation for researching low back pain treatments.
  • Optimized IVDD models can accelerate the development of effective therapies.