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Related Experiment Videos

Aspirin dosing using 15 grain enteric coated tablets.

S Pollet, R H White, H Jang

    The Journal of Rheumatology
    |April 1, 1985
    PubMed
    Summary
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    Twice daily enteric-coated aspirin (975 mg) effectively achieved therapeutic salicylate levels in most participants. This dosing regimen shows promise for feasible anti-inflammatory therapy in arthritis patients.

    Area of Science:

    • Pharmacology
    • Rheumatology

    Background:

    • Aspirin is a common anti-inflammatory drug.
    • Achieving therapeutic salicylate levels is crucial for efficacy.
    • Enteric-coated aspirin may offer improved gastrointestinal tolerance.

    Purpose of the Study:

    • To evaluate the feasibility of achieving therapeutic salicylate levels with a high-unit dose (975 mg) enteric-coated aspirin.
    • To assess the tolerability and efficacy of a twice-daily dosing regimen.

    Main Methods:

    • A study involving 36 normal individuals and arthritis patients.
    • Participants received a 15-grain (975 mg) enteric-coated aspirin preparation twice daily.
    • Salicylate (SA) levels were monitored to determine therapeutic range (150-300 µg/ml).

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    Main Results:

    • 92% (33/36) of participants achieved therapeutic salicylate levels (mean SA = 224 µg/ml).
    • A roughly linear relationship was observed between dose (mg/kg) and steady-state SA levels (r=0.74).
    • Over 90% of subjects on a 45-60 mg/kg/day dose achieved therapeutic levels.

    Conclusions:

    • Twice-daily administration of 975 mg enteric-coated aspirin is a feasible approach for anti-inflammatory therapy.
    • This regimen can effectively achieve therapeutic salicylate levels in a majority of patients.
    • Individual dose adjustments may be necessary to optimize salicylate levels.