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Methotrexate induced false photosensitivity reaction.

R A Neiman, K H Fye

    The Journal of Rheumatology
    |April 1, 1985
    PubMed
    Summary
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    Methotrexate can cause a severe skin reaction after sun exposure, known as a ultraviolet reactivation reaction. This case highlights a rare side effect in rheumatology patients, emphasizing the need for awareness.

    Area of Science:

    • Rheumatology
    • Dermatology
    • Pharmacology

    Background:

    • Methotrexate is a common treatment for various rheumatologic conditions.
    • Sun exposure can sometimes trigger skin reactions in patients.
    • Understanding drug-induced photosensitivity is crucial for patient safety.

    Observation:

    • A patient with polymyositis experienced mild erythroderma after sun exposure.
    • The rash significantly worsened into intense dermatitis and bullae within 24 hours of receiving methotrexate.
    • This exacerbation occurred after the initial sun-induced rash had begun to resolve.

    Findings:

    • The patient presented with a methotrexate-induced ultraviolet reactivation reaction.
    • This reaction is also termed a "false photosensitivity" reaction.

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  • The event was documented as a severe cutaneous adverse reaction to methotrexate.

    • Implications:

    • This case highlights a previously underreported adverse reaction in rheumatologic literature.
    • Clinicians should be aware of ultraviolet reactivation reactions to methotrexate.
    • Prompt recognition and management are essential to prevent severe dermatologic complications.