Related Experiment Video
Updated: May 9, 2025
A 3D Organotypic Melanoma Spheroid Skin Model
Published on: May 18, 2018
A Retrospective Study of Nevus-Associated Melanoma in situ
Clio Dessinioti1, Angelliki Befon2, Mihaella Plaka1
11st Department of Dermatology-Venereology, Andreas Sygros Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Introduction:
The frequency and type of nevus association in histology in melanoma in situ (MIS) is unclear.
Methods:
We performed a retrospective study to investigate the characteristics, frequency, and type of adjacent nevus in histology (common or dysplastic) in MIS. Lentigo maligna (LM) and in situ acral lentiginous melanomas (ALMs) were excluded.
Results:
From 1991 to 2023, there were 448 available non-LM/non-ALM MIS. MIS was nevus associated (NAM-MIS) in 353 cases (79%). Of these cases, 326 NAM-MIS cases (94%) had dysplastic nevus remnants. Among the dysplastic nevus MIS, 176 (54%) were adjacent with severely dysplastic nevus. Nevus-associated MIS versus de novo MIS was more frequently located on the trunk (54% vs. 36%) and less frequently located on the head/neck (8% vs. 11%) (p = 0.02).
Conclusions:
Nevus association is a common finding in MIS and almost all nevus-associated MIS was associated with a dysplastic nevus. These findings may indicate an evolution from severely dysplastic nevus to MIS and also reflect the equivalent histopathological classification and support their previously proposed biological equivalence as not obligate precursors of invasive melanomas.
