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Updated: May 6, 2026
An Improved Method for the Preparation of Type I Collagen From Skin
Published on: January 22, 2014
Effects of Collagen Supplements on Skin Aging: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Seung-Kwon Myung1, Yunseo Park2
1Department of Public Health & AI, National Cancer Center Graduate School of Cancer Science and Policy, Goyang, Gyeonggi-do, Republic of Korea; Cancer Epidemiology Branch, Division of Cancer Data Science, National Cancer Center Research Institute, Goyang, Gyeonggi-do, Republic of Korea; Department of Family Medicine and Center for Cancer Prevention and Detection, Hospital, National Cancer Center, Goyang, Gyeonggi-do, Republic of Korea.
Background:
Collagen supplements are promoted to help aging skin. However, no meta-analysis of randomized controlled trials (RCTs) has examined their effects by funding source and study quality, which may influence outcomes.
Methods:
PubMed, Embase, and Cochrane Library were searched from inception to June 14, 2024.
Results:
A total of 23 RCTs with 1474 participants were analyzed. In a meta-analysis of all 23 RCTs, collagen supplements significantly improved skin hydration, elasticity, and wrinkles. However, in the subgroup meta-analysis by funding source, studies not receiving funding from pharmaceutical companies revealed no effect of collagen supplements for improving skin hydration, elasticity, and wrinkles, while those receiving funding from pharmaceutical companies did show significant effects. Similarly, high-quality studies revealed no significant effect in all categories, while low-quality studies revealed a significant improvement in elasticity.
Conclusions:
There is currently no clinical evidence to support the use of collagen supplements to prevent or treat skin aging.
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