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The Quantitative Analysis of Solid Dosage Forms of Itopride using Raman Spectroscopy
Iqra Naheed1, Maida Ehsan1, Haq Nawaz1
1Department of Chemistry, University of Agriculture Faisalabad, Faisalabad, 38000, Pakistan.
Current Pharmaceutical Design
|May 6, 2025
Summary
Raman spectroscopy accurately quantifies itopride in solid dosage forms. Principal Component Analysis (PCA) and Partial Least Squares Regression Analysis (PLS-RA) enabled reliable identification and concentration determination.
Area of Science:
- Pharmaceutical analysis
- Spectroscopic techniques
Background:
- Raman spectroscopy offers a non-invasive, rapid, and accurate method for pharmaceutical analysis.
- It is suitable for identifying and quantifying active pharmaceutical ingredients in complex formulations.
Purpose of the Study:
- To explore the application of Raman spectroscopy for identifying and quantifying itopride in solid dosage forms.
- To assess the efficacy of multivariate data analysis techniques for pharmaceutical analysis.
Main Methods:
- Raman spectral features of itopride in solid dosage forms were analyzed.
- Principal Component Analysis (PCA) and Partial Least Squares Regression Analysis (PLS-RA) were employed as multivariate data analysis techniques.
Main Results:
- PCA effectively distinguished Raman spectral data of various itopride drug samples.
- PLS-RA achieved quantitative analysis with an R2 value of 0.999%, indicating excellent model variability explanation.
- The method accurately determined itopride concentration in unknown formulations, with a calculated concentration of 79.66/80 mg (w/w).
Conclusions:
- Raman spectroscopy, coupled with PLS-RA, reliably determines itopride concentration in pharmaceutical samples.
- This method is effective for quality control of solid dosage forms.
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