Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Detection of human papillomavirus infection in oral mucosal diseases: A single-center study.

JADA foundational science·2026
Same author

Color Stability of Single-Shade Resin Composites: A Systematic Review of In Vitro Studies and Clinical Implications.

Dentistry journal·2026
Same author

Radiomics in the Evaluation of Cystic and Neoplastic Lytic Lesions of the Jaws.

Diagnostics (Basel, Switzerland)·2026
Same author

Graphene-Based 3D Scaffolds in Bone Regeneration: Emerging Opportunities for MRONJ Treatment.

Pharmaceutics·2026
Same author

Is There an Association Between Periodontitis and Gestational Diabetes? A Systematic Review and Meta-Analysis.

Dentistry journal·2026
Same author

The Intersection of Non-Communicable Chronic Disease and Endodontic Care: A Pilot Retrospective Cross-Sectional Study.

Dentistry journal·2026

Related Experiment Video

Updated: May 1, 2026

Dry Film Photoresist-based Electrochemical Microfluidic Biosensor Platform: Device Fabrication, On-chip Assay Preparation, and System Operation
13:42

Dry Film Photoresist-based Electrochemical Microfluidic Biosensor Platform: Device Fabrication, On-chip Assay Preparation, and System Operation

Published on: September 19, 2017

10.1K

Nanotechnology-Enabled Blood Test for Oral Epithelial Disorders Management: A Proof-of-Concept Study.

Erica Quagliarini1, Giulio Caracciolo1, Francesca Giulimondi1

  • 1NanoDelivery Lab, Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy.

Oral Diseases
|May 6, 2025
PubMed
Summary

This study introduces a novel nanotechnology diagnostic method for oral squamous cell carcinoma and oral potentially malignant disorders. Characterizing the protein corona on graphene oxide nanosheets accurately distinguishes patients from healthy individuals.

Keywords:
biomarkersblood testnanoparticlesoral canceroral potentially malignant disordersprotein corona

More Related Videos

A Blood-based Test for the Detection of ROS1 and RET Fusion Transcripts from Circulating Ribonucleic Acid Using Digital Polymerase Chain Reaction
10:35

A Blood-based Test for the Detection of ROS1 and RET Fusion Transcripts from Circulating Ribonucleic Acid Using Digital Polymerase Chain Reaction

Published on: April 5, 2018

12.6K
µTongue: A Microfluidics-Based Functional Imaging Platform for the Tongue In Vivo
07:53

µTongue: A Microfluidics-Based Functional Imaging Platform for the Tongue In Vivo

Published on: April 22, 2021

3.1K

Related Experiment Videos

Last Updated: May 1, 2026

Dry Film Photoresist-based Electrochemical Microfluidic Biosensor Platform: Device Fabrication, On-chip Assay Preparation, and System Operation
13:42

Dry Film Photoresist-based Electrochemical Microfluidic Biosensor Platform: Device Fabrication, On-chip Assay Preparation, and System Operation

Published on: September 19, 2017

10.1K
A Blood-based Test for the Detection of ROS1 and RET Fusion Transcripts from Circulating Ribonucleic Acid Using Digital Polymerase Chain Reaction
10:35

A Blood-based Test for the Detection of ROS1 and RET Fusion Transcripts from Circulating Ribonucleic Acid Using Digital Polymerase Chain Reaction

Published on: April 5, 2018

12.6K
µTongue: A Microfluidics-Based Functional Imaging Platform for the Tongue In Vivo
07:53

µTongue: A Microfluidics-Based Functional Imaging Platform for the Tongue In Vivo

Published on: April 22, 2021

3.1K

Area of Science:

  • Nanotechnology
  • Biomaterials Science
  • Oncology

Background:

  • Tissue biopsy for oral cancer diagnosis has limitations.
  • Nanotechnology offers advanced detection methods for oral squamous cell carcinoma (OSCC) and oral potentially malignant disorders (OPMD).
  • The protein corona, a biomolecular layer, shows potential in differentiating oncological patients from healthy individuals.

Purpose of the Study:

  • To develop a new diagnostic method for OSCC and OPMD.
  • To utilize personalized protein corona characterization on graphene oxide nanosheets for diagnosis.

Main Methods:

  • Formulated a diagnostic approach using graphene oxide nanosheets.
  • Exposed nanosheets to patient plasma to form a personalized protein corona.
  • Analyzed the protein corona for diagnostic markers.

Main Results:

  • Achieved an overall accuracy of 87% in distinguishing oncological subjects from healthy individuals.
  • Observed a trend of protein profile convergence between patients and healthy subjects during treatment.
  • Demonstrated the method's potential in monitoring disease progression.

Conclusions:

  • The developed protein corona characterization method shows promise for discriminating OSCC and OPMD.
  • This approach could aid in the management of oral diseases.
  • Further validation in larger prospective studies is warranted.