Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Radical Chain-Growth Polymerization: Mechanism01:09

Radical Chain-Growth Polymerization: Mechanism

2.3K
The radical chain-growth polymerization mechanism consists of three steps: initiation, propagation, and termination of polymerization. The polymerization initiates when a free radical generated from the radical initiator adds to the unsaturated bond in the monomer. The unpaired electron of the free radical and one π electron in the unsaturated bond creates a σ bond between the free radical and the monomer. As a result, the other π electron in the unsaturated bond converts this...
2.3K
Olefin Metathesis Polymerization: Overview01:13

Olefin Metathesis Polymerization: Overview

2.0K
Recently, the development of olefin metathesis polymerization advanced the field of polymer synthesis. Simply put, the reorganization of substituents on their double bonds between two olefins in the presence of a catalyst is known as the olefin metathesis reaction. The use of metathesis reaction for polymer synthesis is called olefin metathesis polymerization.
Ruthenium-based Grubbs catalyst is the most commonly used catalyst for olefin metathesis polymerization. Grubbs catalyst consists...
2.0K
Cycloaddition Reactions: Overview01:16

Cycloaddition Reactions: Overview

2.5K
Cycloadditions are one of the most valuable and effective synthesis routes to form cyclic compounds. These are concerted pericyclic reactions between two unsaturated compounds resulting in a cyclic product with two new σ bonds formed at the expense of π bonds. The [4 + 2] cycloaddition, known as the Diels–Alder reaction, is the most common. The other example is a [2 + 2] cycloaddition.
2.5K
Radical Chain-Growth Polymerization: Overview01:10

Radical Chain-Growth Polymerization: Overview

2.2K
Chain-growth or addition polymerization is successive addition reactions of monomers with a polymer chain. In radical chain-growth polymerization, the reaction proceeds via a free-radical intermediate. The free radical is formed from radical initiators, which spontaneously generate free radicals by homolytic fission. Organic peroxides (such as dibenzoyl peroxide, as shown in Figure 1) or azo compounds are popular radical initiators. A low concentration ratio of radical initiator to monomer is...
2.2K
Oxidation of Alkenes: Syn Dihydroxylation with Osmium Tetraoxide02:44

Oxidation of Alkenes: Syn Dihydroxylation with Osmium Tetraoxide

9.6K
Alkenes are converted to 1,2-diols or glycols through a process called dihydroxylation. It involves the addition of two hydroxyl groups across the double bond with two different stereochemical approaches, namely anti and syn. Dihydroxylation using osmium tetroxide progresses with syn stereochemistry.
9.6K
Preparation of 1° Amines: Hofmann and Curtius Rearrangement Mechanism01:26

Preparation of 1° Amines: Hofmann and Curtius Rearrangement Mechanism

3.4K
The Hofmann and Curtius rearrangement reactions can be applied to synthesize primary amines from carboxylic acid derivatives such as amides and acyl azides. In the Hofmann rearrangement, a primary amide undergoes deprotonation in the presence of a base, followed by halogenation to generate an N-haloamide. A second proton abstraction produces a stabilized anionic species, which rearranges to an isocyanate intermediate via an alkyl group migration from the carbonyl carbon to the neighboring...
3.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

L-threo-D-galacto-Octitol: a curious non-classical order-disorder polytype with an 88 Å axis.

Acta crystallographica Section B, Structural science, crystal engineering and materials·2026
Same author

Functional β1-selectivity of novel pyrazoloquinolinones at GABA<sub>A</sub> receptors revealed by electrophysiology, mutagenesis and docking.

European journal of pharmacology·2026
Same author

Silent Partners in the Mill: Unveiling the Role of Additives in Mechanochemical Synthesis.

Chemistry (Weinheim an der Bergstrasse, Germany)·2026
Same author

Diazirines Beyond Photoaffinity Labeling: A Comprehensive Overview of Applications in Biological Sciences, Materials Chemistry, and NMR-Spectroscopy.

Angewandte Chemie (International ed. in English)·2025
Same author

Mechanochemistry Enables Rapid and Solvent-Free Wittig Reactions on Sugars.

ChemSusChem·2025
Same author

Identification of a novel PDE4 inhibitor inspired by leoligin-derived lignans.

European journal of medicinal chemistry·2025
Same journal

VOCs Adsorption and Exchange Properties in Bispidine-Based Mn(II) 1D CPs Made of Orthogonally Oriented Linear Chains.

Chemistry (Weinheim an der Bergstrasse, Germany)·2026
Same journal

Electrosynthesis of Glycine From Nitrate and Glyoxylic Acid Over a Bi<sub>2</sub>S<sub>3</sub> Nanosheets-Based Catalyst.

Chemistry (Weinheim an der Bergstrasse, Germany)·2026
Same journal

Symmetry Breaking in Achiral Porphyrins: Noncovalent Origins of Emergent Optical Activity.

Chemistry (Weinheim an der Bergstrasse, Germany)·2026
Same journal

Modulation of O<sub>2</sub> Affinity and Enzymatic Activity of Core‒Shell Structured Hemoglobin Nanoparticles.

Chemistry (Weinheim an der Bergstrasse, Germany)·2026
Same journal

Stepwise Synthesis of Tetrabenzotriazaporphyrins (TBTAPs) and Their Open 2- and 3-Ring Fragments.

Chemistry (Weinheim an der Bergstrasse, Germany)·2026
Same journal

Geometry-Based Neural-Network Prediction of Electron Localization Function Topology in Dense Hydrogen.

Chemistry (Weinheim an der Bergstrasse, Germany)·2026
See all related articles

Related Experiment Video

Updated: May 9, 2025

Reliable Mechanochemistry: Protocols for Reproducible Outcomes of Neat and Liquid Assisted Ball-mill Grinding Experiments
13:05

Reliable Mechanochemistry: Protocols for Reproducible Outcomes of Neat and Liquid Assisted Ball-mill Grinding Experiments

Published on: January 23, 2018

10.5K

Advances in Mechanochemical Methods for One-Pot Multistep Organic Synthesis.

Michael Schnürch1, Nina Biedermann1

  • 1Institute of Applied Synthetic Chemistry, TU Wien, Getreidemarkt 9/163, Vienna, 1060, Austria.

Chemistry (Weinheim an Der Bergstrasse, Germany)
|May 6, 2025
PubMed
Summary
This summary is machine-generated.

Mechanochemical one-pot synthesis offers a greener path for organic chemistry, reducing solvent use and waste. This review explores recent advances in combining multiple reaction steps into a single process for improved efficiency.

Keywords:
ball millingliquid‐assisted grindingmechanochemistrysolvent freesustainable synthesis

More Related Videos

Versatile CO2 Transformations into Complex Products: A One-pot Two-step Strategy
07:36

Versatile CO2 Transformations into Complex Products: A One-pot Two-step Strategy

Published on: November 9, 2019

7.9K
Author Spotlight: Accelerating Discovery in Microporous Material Chemistry
07:20

Author Spotlight: Accelerating Discovery in Microporous Material Chemistry

Published on: October 6, 2023

3.4K

Related Experiment Videos

Last Updated: May 9, 2025

Reliable Mechanochemistry: Protocols for Reproducible Outcomes of Neat and Liquid Assisted Ball-mill Grinding Experiments
13:05

Reliable Mechanochemistry: Protocols for Reproducible Outcomes of Neat and Liquid Assisted Ball-mill Grinding Experiments

Published on: January 23, 2018

10.5K
Versatile CO2 Transformations into Complex Products: A One-pot Two-step Strategy
07:36

Versatile CO2 Transformations into Complex Products: A One-pot Two-step Strategy

Published on: November 9, 2019

7.9K
Author Spotlight: Accelerating Discovery in Microporous Material Chemistry
07:20

Author Spotlight: Accelerating Discovery in Microporous Material Chemistry

Published on: October 6, 2023

3.4K

Area of Science:

  • Organic Chemistry
  • Green Chemistry
  • Materials Science

Background:

  • Conventional solution-based synthesis often involves significant solvent use, lengthy reaction times, and complex purification steps.
  • Mechanochemistry offers a sustainable alternative by utilizing mechanical force to drive chemical reactions, minimizing or eliminating solvent requirements.
  • One-pot multistep reactions streamline synthetic processes by performing sequential transformations in a single reaction vessel, reducing waste and operational complexity.

Purpose of the Study:

  • To review recent advancements in mechanochemical one-pot multistep reactions in organic synthesis.
  • To highlight the operational and environmental benefits of these sustainable methodologies.
  • To discuss the current challenges and future potential of mechanochemical one-pot synthesis.

Main Methods:

  • Focus on protocols employing sequential one-pot operation in mechanochemical synthesis.
  • Cover diverse organic transformations, including heterocycle formation and functional group interconversions.
  • Include examples of active pharmaceutical ingredient synthesis using these methods.

Main Results:

  • Mechanochemical one-pot reactions demonstrate reduced solvent usage, shorter reaction times, and simplified procedures.
  • Integration of multiple steps eliminates intermediate workup and purification, leading to less waste.
  • Successful application in various organic transformations, including complex molecule synthesis.

Conclusions:

  • Mechanochemical one-pot synthesis presents a powerful and sustainable strategy for modern organic chemistry.
  • These methods streamline synthetic pathways, offering significant environmental and operational advantages.
  • Further development is needed to address remaining challenges and expand the scope of these green synthetic techniques.