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Relationship between C-reactive protein-albumin ratio and prognosis in pediatric patients with severe burns

Serap Samut Bülbül1, Alper Ceylan2, Metin Ocak3

  • 1Faculty of Medicine, Department of Pediatric Surgery, Samsun University, Samsun, Turkey.

Plos One
|May 6, 2025
PubMed

Insights

In children with severe burns, a high C-reactive protein (CRP) to albumin ratio at admission indicates a longer hospital stay. This ratio can help predict length of stay (LOS) in pediatric burn patients.

Area of Science:

  • Biochemistry
  • Clinical Medicine
  • Pediatrics

Background:

  • C-reactive protein (CRP) is a key acute-phase reactant.
  • Albumin levels can be affected by severe illness and injury.
  • The CRP-albumin ratio may offer insights into patient prognosis.

Purpose of the Study:

  • To examine the association between albumin, CRP, and CRP-albumin ratio with hospital length of stay (LOS) in pediatric severe burn patients.
  • To determine if these biomarkers can predict LOS in this population.

Main Methods:

  • Retrospective analysis of 150 pediatric patients with third- and fourth-degree burns.
  • Data collected between January 2019 and September 2023.
  • Statistical analysis to correlate biomarker levels (albumin, CRP, CRP-albumin ratio) with hospital LOS.

Main Results:

  • A significantly lower mean CRP-albumin ratio was observed in patients with LOS ≤10 days compared to those with longer stays (p < 0.001).
  • Patients with LOS of 21-30 days and >40 days showed significantly higher rates of elevated CRP-albumin ratios (p < 0.001).
  • Hospital LOS demonstrated a significant positive correlation with CRP-albumin ratios (p < 0.001; r = 0.529).

Conclusions:

  • Low albumin, high CRP, and elevated CRP-albumin ratios at admission may correlate with clinical presentation in pediatric severe burn patients.
  • The CRP-albumin ratio is a significant predictor of hospital length of stay in children with severe burns.
  • These findings suggest the utility of the CRP-albumin ratio in managing and predicting outcomes for pediatric burn patients.

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