Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Psychoneuroimmunology: Cardiovascular Disease01:27

Psychoneuroimmunology: Cardiovascular Disease

26
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
26
Post-traumatic Stress Disorder01:27

Post-traumatic Stress Disorder

30
Post-traumatic stress disorder (PTSD) is a psychiatric condition that arises following exposure to traumatic events such as natural disasters, forced displacement, or severe accidents. It significantly impairs individuals' ability to cope with daily activities and disrupts their emotional and psychological equilibrium.
Symptoms and Behavioral Manifestations
A spectrum of distressing symptoms characterizes PTSD. Recurrent flashbacks, where individuals involuntarily relive traumatic events,...
30
Introduction to Stress and Lifestyle01:27

Introduction to Stress and Lifestyle

88
Stress is a multifaceted response to events perceived as challenging or threatening, highlighting physical, emotional, cognitive, and behavioral reactions. Physically, stress can lead to fatigue, sleep disruptions, and various health issues such as frequent colds, chest pains, and nausea. Emotionally, it can manifest as anxiety, depression, irritability, and anger triggered by both minor and major life events. Cognitively, it may result in difficulty in concentration, memory, and...
88
Stress and Mental Health01:30

Stress and Mental Health

84
Chronic stress profoundly affects mental health, significantly influencing mood, behavior, and overall quality of life. Research closely links chronic stress with mental health conditions such as depression, anxiety, and substance use disorders. Ongoing exposure to stress can lead to physiological and psychological changes, initiating a cycle of emotional distress and maladaptive coping mechanisms.
Individuals with depression often experience challenges in both their personal and professional...
84
Exercise and Cardiovascular Response01:20

Exercise and Cardiovascular Response

745
Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
745
Psychological Responses to Stress01:20

Psychological Responses to Stress

47
Psychological responses to stress encompass the various cognitive and emotional reactions individuals experience when faced with challenging or threatening situations, such as a job loss. Prolonged exposure to stressors can disturb emotional balance, increasing negative emotions (e.g., anxiety and sadness) and diminishing positive emotions (e.g., joy and satisfaction). These persistent emotional shifts are associated with an increased risk of both physical illness and mental health issues, such...
47

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Type 2 Myocardial Infarction: Do We Need Risk Scores?

Journal of the American College of Cardiology·2023
Same author

Accuracy and Clinical Impact of Estimating Low-Density Lipoprotein-Cholesterol at High and Low Levels by Different Equations.

Biomedicines·2022
Same author

Artificial intelligence-augmented electrocardiography for left ventricular systolic dysfunction in patients undergoing high-sensitivity cardiac troponin T.

European heart journal. Acute cardiovascular care·2022
Same author

Measuring copeptin, a surrogate for vasopressin in patients with hypertension - Can it identify those who are volume Responsive?

Clinical biochemistry·2022
Same author

Implementation of High-Sensitivity Cardiac Troponin Assays in the United States.

Journal of the American College of Cardiology·2022
Same author

The retirement of CKMB.

European heart journal. Acute cardiovascular care·2022
Same journal

A prospective, randomized exploratory study: Association of preemptive analgesia combined with preoperative transnasal insulin therapy with reduced postoperative delirium in elderly patients undergoing lower extremity fracture surgery.

General hospital psychiatry·2026
Same journal

Short-term ECG safety after inpatient initiation of sertraline versus citalopram or escitalopram: An observational target-trial emulation using MIMIC-IV-ECG.

General hospital psychiatry·2026
Same journal

Patient- and ward-level determinants of psychosomatic-psychiatric consultations for mentally distressed inpatients from medical hospitals: Findings from the SomPsyNet stepped-wedge-trial.

General hospital psychiatry·2026
Same journal

Self-stigma as a central barrier to psychological help-seeking among patients receiving ambulatory Orthopedic care: Paradoxical associations of anxiety and depressive symptoms.

General hospital psychiatry·2026
Same journal

Therapeutic approaches for functional Globus Pharyngeus: A systematic review of studies from 2000 to 2025.

General hospital psychiatry·2026
Same journal

Quetiapine Versus Haloperidol for the Treatment of Delirium in Hospitalized Adults: A Meta-Analysis of Randomized Controlled Trials with Trial Sequential Analysis.

General hospital psychiatry·2026
See all related articles

Related Experiment Video

Updated: Jun 12, 2025

Polar Histogram Visualization of Acute Stress Disorder Scale Scores for Comprehensive Clinical Assessment
08:25

Polar Histogram Visualization of Acute Stress Disorder Scale Scores for Comprehensive Clinical Assessment

Published on: December 6, 2024

321

Large decrease in posttraumatic stress disorder severity and cardiovascular disease outcomes.

Joanne Salas1, Poorva Sheth2, Beth E Cohen3

  • 1The Advanced HEAlth Data (AHEAD) Research Institute, Saint Louis University School of Medicine. 1402 South Grand Blvd, St. Louis, MO, United States; Department of Health and Clinical Outcomes Research, Saint Louis University School of Medicine, 1402 South Grand Blvd, St. Louis, MO, United States.

General Hospital Psychiatry
|May 6, 2025
PubMed
Summary
This summary is machine-generated.

Significant reductions in posttraumatic stress disorder (PTSD) severity did not improve cardiovascular disease (CVD) outcomes in veterans. Further research is needed to confirm these findings in diverse patient groups with comorbid PTSD and CVD.

Keywords:
Cardiovascular diseaseEpidemiologyPsychiatryVeterans

More Related Videos

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents
06:55

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents

Published on: December 2, 2015

22.4K
Simultaneous Application of Transcranial Direct Current Stimulation during Virtual Reality Exposure
08:20

Simultaneous Application of Transcranial Direct Current Stimulation during Virtual Reality Exposure

Published on: January 18, 2021

4.0K

Related Experiment Videos

Last Updated: Jun 12, 2025

Polar Histogram Visualization of Acute Stress Disorder Scale Scores for Comprehensive Clinical Assessment
08:25

Polar Histogram Visualization of Acute Stress Disorder Scale Scores for Comprehensive Clinical Assessment

Published on: December 6, 2024

321
An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents
06:55

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents

Published on: December 2, 2015

22.4K
Simultaneous Application of Transcranial Direct Current Stimulation during Virtual Reality Exposure
08:20

Simultaneous Application of Transcranial Direct Current Stimulation during Virtual Reality Exposure

Published on: January 18, 2021

4.0K

Area of Science:

  • Cardiology
  • Psychiatry
  • Public Health

Background:

  • Posttraumatic stress disorder (PTSD) is a known risk factor for cardiovascular disease (CVD).
  • While physical health improvements are often seen with reduced PTSD severity, the impact on CVD outcomes in comorbid cases is unclear.
  • This study investigates the relationship between PTSD improvement and CVD outcomes in a veteran population.

Purpose of the Study:

  • To determine if clinically meaningful improvement in PTSD symptoms is associated with better cardiovascular outcomes.
  • To analyze the association between PTSD severity reduction and risks for myocardial infarction, revascularization, all-cause mortality, and stroke.
  • To explore potential modifications of this association by race, age, or depression.

Main Methods:

  • A cohort of 7120 veterans with PTSD and comorbid CVD was analyzed using de-identified medical records (2011-2022).
  • Clinically meaningful PTSD improvement was defined as a ≥20-point decrease on the PTSD Checklist (PCL).
  • Cox proportional hazard models, controlled for confounding via entropy balance, assessed the association between PTSD improvement and CVD outcomes.

Main Results:

  • Clinically meaningful PTSD improvement was observed in 20.4% of the veteran sample.
  • No significant differences in the risk of myocardial infarction/revascularization, all-cause mortality, or stroke were found between patients with and without clinically meaningful PTSD improvement.
  • Race, age, and depression did not significantly modify the association between PTSD improvement and adverse CVD outcomes.

Conclusions:

  • In this cohort of veterans with comorbid PTSD and CVD, substantial reductions in PTSD severity were not linked to improved or worsened cardiovascular outcomes.
  • Further research is required to ascertain if this lack of association between PTSD improvement and CVD outcomes is consistent across other patient populations.
  • The findings highlight the complex interplay between mental health and cardiovascular health in veteran populations.