Related Experiment Video

Updated: May 9, 2025

Author Spotlight: Exploring Self-Assembled MOF-Polymer Composites
06:48

Author Spotlight: Exploring Self-Assembled MOF-Polymer Composites

Published on: June 14, 2024

1.4K

[m6A modification regulates PLK1 expression and mitosis]

Xiaoli Chang1, Xin Yan1, Zhenyu Yang2

  • 1College of Veterinary Medicine, Shanxi Agricultural University, Jinzhong 030801, Shanxi, China.

Sheng Wu Gong Cheng Xue Bao = Chinese Journal of Biotechnology
|May 6, 2025
PubMed

Insights

N-methyladenosine (m6A) levels rise during mitosis, impacting cell cycle regulation. This study reveals m6A controls Polo-like kinase 1 (PLK1) translation, crucial for mitotic progression and cell homeostasis.

Area of Science:

  • Epigenetics and molecular biology
  • Cellular and molecular mechanisms of cell cycle control
  • RNA modifications and gene expression regulation

Context:

  • N6-methyladenosine (m6A) is a prevalent RNA modification implicated in various cellular processes.
  • The precise role and mechanisms of m6A in regulating mitosis are not fully understood.
  • Mitosis is a fundamental process for cell division, and its dysregulation is linked to diseases like cancer.

Purpose:

  • To investigate the role of m6A modification in regulating mitosis.
  • To identify specific m6A targets involved in mitotic control.
  • To elucidate the mechanism by which m6A influences mitotic progression.

Summary:

  • m6A modification levels increase during mitosis.
  • Silencing METTL3 or METTL14 leads to mitotic delay and defects in spindle assembly and chromosome segregation.
  • Polo-like kinase 1 (PLK1) was identified as a key m6A target; m6A modification inhibits PLK1 translation via YTHDF1, maintaining cell cycle homeostasis.
  • Demethylation of PLK1 mRNA results in mitotic abnormalities.

Impact:

  • This research elucidates a novel mechanism of m6A-mediated regulation of mitosis.
  • Identifies PLK1 as a critical m6A target in mitotic control.
  • Highlights the potential of targeting m6A pathways for therapeutic interventions in proliferative diseases, including cancer.
Keywords:
cell cyclemethyltransferase-like 3 (METTL3)mitosispolo-like kinase 1 (PLK1)

More Related Videos

Mapping Molecular Diffusion in the Plasma Membrane by Multiple-Target Tracing MTT12:19

Mapping Molecular Diffusion in the Plasma Membrane by Multiple-Target Tracing MTT

Published on: May 27, 2012

17.2K
Optimizing Magnetic Force Microscopy Resolution and Sensitivity to Visualize Nanoscale Magnetic Domains07:42

Optimizing Magnetic Force Microscopy Resolution and Sensitivity to Visualize Nanoscale Magnetic Domains

Published on: July 20, 2022

2.6K

Related Concept Videos

Thomson's e/m Experiment01:19

Thomson's e/m Experiment

In a beam of charged particles created by a heated cathode, the particles move at different speeds. However, many applications need a beam with uniform particle speeds. An arrangement known as a velocity selector uses electric and magnetic fields to pick particles with a particular speed from the beam.
A particle with charge q, speed v, and mass m enters an area from the top, where the magnetic and electric fields are perpendicular both to the particle's motion and to one another. The...
2.9K
Molar Mass01:54

Molar Mass

The identity of a substance is defined not only by the types of atoms or ions it contains but by the quantity of each type of atom or ion. For example, water, H2O, and hydrogen peroxide, H2O2, are alike in that their respective molecules are composed of hydrogen and oxygen atoms. However, because a hydrogen peroxide molecule contains two oxygen atoms, as opposed to the water molecule, which has only one, the two substances exhibit very different properties.
68.5K
Hückel's Rule Diagram of π MOs: Frost Circle01:08

Hückel's Rule Diagram of π MOs: Frost Circle

The Frost circle or the inscribed polygon method is a graphical method for determining the relative energies of π molecular orbitals (MOs) for planar, fully conjugated, and monocyclic compounds. This method was first described by A. A. Frost and Boris Musulin in 1953.
A Frost circle is constructed by drawing a polygon whose number of edges is equal to the number of carbons of the given cyclic system, with one of the vertices pointing down. Then, a circle is drawn enclosing the polygon so...
4.2K
Mass Moment of Inertia: Problem Solving01:13

Mass Moment of Inertia: Problem Solving

Knowing how to determine the moment of inertia in a wheel's axle can be invaluable in engineering and automotive applications. It provides an understanding of how changes in geometry, mass, and radius can impact its performance.
The axle can be approximated to a solid cylinder with longitudinal and perpendicular axes. Initially, a thin disc is considered parallel to the circular face of the cylinder.
259
Conservation of Angular Momentum: Application01:18

Conservation of Angular Momentum: Application

A system's total angular momentum remains constant if the net external torque acting on the system is zero. Examples of such systems include a freely spinning bicycle tire that slows over time due to torque arising from friction, or the slowing of Earth's rotation over millions of years due to frictional forces exerted on tidal deformations. However in the absence of a net external torque, the angular momentum remains conserved. The conservation of angular momentum principle requires a...
10.6K
Tandem Mass Spectrometry01:21

Tandem Mass Spectrometry

Tandem mass spectrometry is a technique that uses multiple mass analyzers in series to obtain a higher selectivity and signal-to-noise ratio for the analyte. Instruments with multiple analyzers separated by an interaction cell enable secondary fragmentation and selected study of the fragment ions.
Secondary fragmentations occur in the interaction cell and can be induced by various factors. Fragmentation induced by collision with inert gases, such as N2, Ar, He, etc., is called collision-induced...
766