Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Overview of Microscopy Techniques

Overview of Microscopy Techniques

The early pioneers of microscopy opened a window into the invisible world of microorganisms. In 1830, Joseph Jackson Lister created an essentially modern light microscope. The 20th century saw the development of microscopes that leveraged nonvisible light, such as fluorescence microscopy that uses an ultraviolet light source and electron microscopy that uses short-wavelength electron beams. These advances significantly improved magnification, image resolution, and contrast. By comparison, the...

Imaging Biological Samples with Optical Microscopy

Imaging Biological Samples with Optical Microscopy

Optical microscopy uses optic principles to provide detailed images of samples. Antonie van Leeuwenhoek designed the first compound optical microscope in the 17th century to visualize blood cells, bacteria, and yeast cells. In 1830, Joseph Jackson Lister created an essentially modern light microscope. The 20th century saw the development of microscopes with enhanced magnification and resolution.
In optical microscopy, the specimen to be viewed is placed on a glass slide and clipped on the stage...

Confocal Fluorescence Microscopy

Confocal Fluorescence Microscopy

Confocal microscopy is an advanced microscopic technique. The prime advantage of the confocal microscope over other microscopy techniques is its ability to block the out-of-focus light from the illuminated samples using pinholes. It is widely used with fluorescence optics to obtain high-resolution, sharp contrast images. Unlike optical microscopes, confocal microscopes use a focused beam of light laser to scan the entire sample surface at different z-planes. These microscopes are, therefore,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Research on SAR Image Target Recognition Method Based on Multi-Dimensional Feature Fusion.

Sensors (Basel, Switzerland)·2026

Same author

Porcine Erythrocyte-PRRSV Interactions: Implications for Targeted Nanodrug Delivery.

Veterinary sciences·2026

Same author

Integrated Network Pharmacology and Cross-Species Analysis Suggest a Potential Role of AKT1/HIF1A Axis in Shuanghuanglian for Pneumonia-Myocarditis Comorbidity.

Veterinary sciences·2026

Same author

Effect of bio-ink physical properties on droplet volume in the reactive jet impingement 3D bioprinting system.

Journal of the mechanical behavior of biomedical materials·2026

Same author

Canine mammary tumors: a bibliometric and visualized analysis from 2009 to 2025.

BMC veterinary research·2026

Same author

Identification of SNPs Associated With mRNA Expression Differences of the Complement Receptor Type 1-Like Gene in Landrace Weaned Piglets.

Veterinary medicine and science·2026

Same journal

Time-averaged simulated microgravity ameliorates tau-induced deficit in Drosophila melanogaster.

NPJ microgravity·2026

Same journal

The impact of 14-day head-down bed rest with or without an exercise countermeasure on standing balance control: a randomized controlled trial.

NPJ microgravity·2026

Same journal

Simulated microgravity weakens wheat root microbial network against pathogens.

NPJ microgravity·2026

Same journal

Effects of the space environment on articular cartilage homeostasis: a review.

NPJ microgravity·2026

Same journal

Communication delay increases procedure time and instructor task load during simulated suturing by novices.

NPJ microgravity·2026

Same journal

Long-term molecular effects of <sup>16</sup>O-ion exposure in rat brain and implications for space radiation risk.

NPJ microgravity·2026

See all related articles

Search research articles

Related Experiment Video

Updated: May 12, 2025

Reduced-gravity Environment Hardware Demonstrations of a Prototype Miniaturized Flow Cytometer and Companion Microfluidic Mixing Technology

Reduced-gravity Environment Hardware Demonstrations of a Prototype Miniaturized Flow Cytometer and Companion Microfluidic Mixing Technology

Published on: November 13, 2014

Microscopy with microfluidics in microgravity using FlightScope.

Thomas Wareing¹, Alexander Stokes¹, Katrina E Crompton²

¹School of Engineering, Newcastle University, Newcastle-Upon-Tyne, NE2 4HH, UK.

NPJ Microgravity

|May 6, 2025

Summary

This summary is machine-generated.

Studying microgravity

More Related Videos

Single Plane Illumination Module and Micro-capillary Approach for a Wide-field Microscope

Single Plane Illumination Module and Micro-capillary Approach for a Wide-field Microscope

Published on: August 15, 2014

Video-rate Scanning Confocal Microscopy and Microendoscopy

Video-rate Scanning Confocal Microscopy and Microendoscopy

Published on: October 20, 2011

Related Experiment Videos

Last Updated: May 12, 2025

Reduced-gravity Environment Hardware Demonstrations of a Prototype Miniaturized Flow Cytometer and Companion Microfluidic Mixing Technology

Reduced-gravity Environment Hardware Demonstrations of a Prototype Miniaturized Flow Cytometer and Companion Microfluidic Mixing Technology

Published on: November 13, 2014

Single Plane Illumination Module and Micro-capillary Approach for a Wide-field Microscope

Single Plane Illumination Module and Micro-capillary Approach for a Wide-field Microscope

Published on: August 15, 2014

Video-rate Scanning Confocal Microscopy and Microendoscopy

Video-rate Scanning Confocal Microscopy and Microendoscopy

Published on: October 20, 2011

Area of Science:

Space Biology
Cellular Biology
Biotechnology

Background:

Space exploration necessitates understanding microgravity's biological effects.
Parabolic flights offer accessible microgravity research but have limitations.
Real-time cellular analysis requires live-imaging capabilities.

Purpose of the Study:

To develop a novel platform for studying dynamic cellular processes during microgravity exposure.
To overcome the limitations of traditional parabolic flight experiments.

Main Methods:

Development of FlightScope, an integrated microscopy and microfluidics system.
Utilizing parabolic flights as a microgravity research platform.
Live-imaging of cellular processes under simulated microgravity.

Main Results:

FlightScope enables real-time observation of cellular dynamics.
The platform addresses challenges of short microgravity duration and vibration.
Successful demonstration of live-imaging in a microgravity research environment.

Conclusions:

FlightScope is a viable tool for microgravity cell biology research.
The platform supports the study of dynamic cellular processes in space.
Advancing research for future space missions to the Moon and Mars.