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Current Concepts in Histiocytic Neoplasms.

Neval Ozkaya1, Elaine S Jaffe2

  • 1Department of Pathology, University of Chicago Medicine, Chicago, IL.

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Summary
This summary is machine-generated.

The International Consensus Classification (ICC) updates histiocytic neoplasm classification, recognizing Rosai-Dorfman-Destombes disease and ALK-positive histiocytosis. This review details ICC diagnostic criteria for these macrophage and dendritic cell disorders.

Keywords:
ICCLangerhansdendritic cellhistiocytosis

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Area of Science:

  • Hematology
  • Oncology
  • Pathology

Background:

  • Histiocytic neoplasms originate from the mononuclear phagocyte system, presenting a wide clinical spectrum.
  • Recent molecular diagnostic advances have refined understanding of these disorders.
  • The World Health Organization (WHO) classification has been updated.

Purpose of the Study:

  • To review current concepts in histiocytic neoplasms.
  • To focus on diagnostic criteria recommended by the International Consensus Classification (ICC).

Main Methods:

  • Review of histopathology, immunophenotype, and molecular alterations.
  • Integration of clinical and imaging characteristics for diagnosis.
  • Comparison with previous WHO classification updates.

Main Results:

  • The ICC recognizes Rosai-Dorfman-Destombes disease as a neoplastic disorder.
  • ALK-positive histiocytosis is introduced as a distinct entity in the ICC.
  • The ICC provides updated diagnostic criteria for histiocytic neoplasms.

Conclusions:

  • The ICC represents a significant update in the classification of histiocytic neoplasms.
  • Accurate diagnosis relies on a multi-faceted approach including morphology, immunophenotype, molecular data, and clinical features.
  • These updates enhance the understanding and management of histiocytic disorders.