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Updated: May 12, 2025

Basophil Activation Test for Allergy Diagnosis
Published on: May 31, 2021
The Role of Basophils in Atopic Dermatitis, from Pathogenesis to Therapeutic Perspectives
Pan Wang1,2, Zheng Su2, Chen Sun2
1School of Medicine, Sun Yat-Sen University, Shenzhen, People's Republic of China.
Abstract:
Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by intense pruritus. The principal pathological features include abnormalities in the structure and function of the epidermis, as well as skin inflammation marked by the overexpression of T helper 2 cell (Th2) cytokines. Throughout the progression of AD, various immune cells contribute to its pathogenesis. Basophils, the least abundant granulocytes in the human peripheral circulation, have historically been overlooked. However, the advent of novel research tools has facilitated a renewed focus on the role of basophils in diverse physiological and pathological conditions, including AD. Accordingly, this review will primarily summarize the association between AD and basophils, the alterations observed in basophils among AD patients, and the implications of these changes for AD patients.
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