Relationships between Cardio-Ankle Vascular Index and Peptides Related to Hypertensive Disorders of Pregnancy in

Related Experiment Video

Updated: May 12, 2025

Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues
08:41

Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues

Published on: June 3, 2019

9.7K

Ichiro Wakabayashi1, Yoko Sotoda2

  • 1Department of Environmental and Preventive Medicine, School of Medicine, Hyogo Medical University, Nishinomiya, Japan.

Pulse (Basel, Switzerland)
|May 7, 2025
PubMed

Insights

Two hypertensive disorder of pregnancy (HDP)-related peptides, P-2091 and P-2378, correlate with diff-CAVI, an indicator of leg ischemia in lower extremity arterial disease (LEAD) patients. These peptides may serve as novel biomarkers for assessing leg ischemia severity in LEAD.

Area of Science:

  • Vascular Medicine
  • Biomarker Discovery
  • Cardiovascular Research

Background:

  • Cardio-ankle vascular index (CAVI) measures arterial stiffness, independent of blood pressure.
  • The difference in CAVI between legs (diff-CAVI) is a potential indicator for leg ischemia in lower extremity arterial disease (LEAD).
  • Hypertensive disorders of pregnancy (HDP)-related peptides are investigated as potential biomarkers for leg ischemia.

Purpose of the Study:

  • To investigate the relationship between diff-CAVI and serum levels of seven HDP-related peptides in LEAD patients.
  • To determine if HDP-related peptides can serve as biomarkers for leg ischemia in LEAD.

Main Methods:

  • 165 outpatients with LEAD receiving medication therapy were studied.
  • Serum levels of seven HDP-related peptides were measured using mass spectrometry.
  • Correlations between diff-CAVI and peptide levels were analyzed, including multivariate analyses.

Main Results:

  • Peptides P-2091 and P-2378 showed significant positive correlations with diff-CAVI.
  • Higher tertiles of P-2091 and P-2378 were associated with significantly higher odds of large diff-CAVI (≥1.05).
  • These associations remained significant and independent of common risk factors in multivariate analyses.

Conclusions:

  • HDP-related peptides P-2091 and P-2378 are associated with diff-CAVI in LEAD patients.
  • These peptides show potential as useful indicators for leg ischemia in patients with LEAD.
Abstract

Keywords:
Cardio-ankle vascular indexHypertensive disorders of pregnancyLeg ischemiaLower extremity arterial diseasePeptide biomarkers

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