A Subepithelial Lesion in the Colon Masquerading as Metastatic Prostate Cancer.

Area of Science:

• Gastroenterology
• Oncology
• Urology

Background:

• Colorectal metastasis is uncommon, with prostate cancer spread to the colon being particularly rare.
• Locoregional penetration in advanced prostate cancer can lead to colon infiltration, often visible during flexible sigmoidoscopy.

Observation:

• A patient with a history of prostate cancer presented with imaging findings of sigmoid colon uptake.
• Endoscopic examination revealed a subepithelial lesion in the sigmoid colon.

Findings:

• Endoscopic ultrasound-guided fine-needle biopsy confirmed the subepithelial lesion to be metastatic prostate cancer.
• This represents the first reported case of prostate cancer metastasis presenting as a subepithelial colonic lesion.

Implications:

• Highlights the importance of considering unusual metastatic patterns in prostate cancer patients.
• Suggests the need for advanced imaging and biopsy techniques for diagnosing rare colonic metastases.
• May influence diagnostic protocols for patients with known prostate cancer and unexplained colonic findings.