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Updated: May 12, 2025

Generation of 3-D Collagen-based Hydrogels to Analyze Axonal Growth and Behavior During Nervous System Development
Published on: June 25, 2019
Review of collagen type I-based hydrogels: focus on composition-structure-properties relationships
Mariana Pires Figueiredo1, Silvia Rodríguez-Fernández1, Francesco Copes1
1Laboratory for Biomaterials and Bioengineering, Canada Research Chair Tier I for the Innovation in Surgery, Department of Min-Met-Materials Engineering and Regenerative Medicine, CHU de Quebec Research Center, Laval University, Quebec City, QC Canada.
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This review explores each stage of Collagen type I (Coll-I) hydrogel development, highlighting how sourcing, extraction, solubilization, and modification (e.g., blending, crosslinking, and composite formation) influence its gelation, and structural, mechanical, and biological properties. By clarifying key interrelations among these characteristics, this work serves as a valuable guide for scientists designing next-generation of Coll-I-based hydrogels with optimized properties for tissue engineering and regenerative medicine applications.

