Smart Polymer Microspheres: Preparation, Microstructures, Stimuli-Responsive Properties, and Applications

Smart polymer microspheres (SPMs) are a class of stimulus-responsive materials that undergo physical, chemical, or property changes in response to external stimuli, such as temperature, pH, light, and magnetic fields. In recent years, their diverse responsiveness and tunable structures have enabled broad applications in biomedicine, environmental protection, information encryption, and other fields. This study provides a detailed review of recent preparation methods of SPMs, focusing on physical methods such as emulsification-solvent evaporation, microfluidics, and electrostatic spraying as well as chemical approaches such as emulsion and precipitation polymerization. Meanwhile, different types of stimulus-responsive behaviors, such as temperature-, pH-, light-, and magnetic-responsiveness, are thoroughly examined. This study also explores the applications of SPMs in drug delivery, tissue engineering, and environmental monitoring, while discussing future technological challenges and development directions in this field.