4D-Printed Intelligent Reconfigurable Occluder With Anti-Thrombotic and Rapid-Repairing Capabilities for Patent...

Area of Science:

• Biomaterials Science
• Medical Devices
• Regenerative Medicine

Background:

• Patent foramen ovale (PFO) closure is effective, but current devices face challenges with slow endothelialization, leading to complications.
• Developing advanced occluders is crucial to mitigate risks like thrombosis and improve integration with cardiac tissue.

Purpose of the Study:

• To design and evaluate a 4D-printed, intelligent, reconfigurable PFO occluder with enhanced pro-endothelialization, anti-thrombotic properties, and bioabsorbability.
• To explore the potential of combining occluder implantation with topical drug delivery for stroke prevention.

Main Methods:

• Fabrication of a 4D-printed occluder utilizing biomimetic design principles for cardiac tissue compatibility.
• In vitro degradation studies and in vivo histological examinations to assess bioabsorbability.
• Anti-thrombosis experiments and evaluation of endothelialization markers (VWF, CD31) to demonstrate efficacy.

Main Results:

• The 4D-printed occluder demonstrated successful bioabsorbability through in vitro and in vivo assessments.
• Preliminary anti-thrombosis experiments indicated significant efficacy.
• Validation of superior pro-endothelialization capabilities through effective expression of VWF and CD31 markers.

Conclusions:

• The developed 4D-printed occluder offers an integrated approach for PFO treatment, combining mechanical occlusion with targeted drug delivery.
• This innovative device presents a viable strategy to enhance healing, prevent thrombosis, and potentially reduce stroke risk in PFO patients.