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Lipoprotein(a) Concentration and Cardiovascular Disease in a Group of Patients With Familial Hypercholesterolemia-A

J Kurdziel1, A Fedak2, E Kawalec3

  • 1Department of Metabolic Diseases and Diabetology, University Hospital, Krakow, Poland.

Clinical Cardiology
|May 7, 2025
PubMed

Insights

High levels of Lipoprotein(a) (Lp(a)) are common in hypercholesterolemic patients and strongly associated with coronary artery disease (CAD). However, Lp(a) levels did not correlate with carotid atherosclerosis in this study group.

Area of Science:

  • Cardiology
  • Lipidology
  • Vascular Medicine

Background:

  • Elevated Lipoprotein(a) (Lp(a)) concentrations are a known risk factor for cardiovascular disease (CVD).
  • Further research is needed to understand Lp(a)'s role in CVD across different vascular beds.

Purpose of the Study:

  • To determine the prevalence of elevated Lp(a) levels in hypercholesterolemic patients.
  • To investigate the association between Lp(a) levels and CVD in this patient cohort.

Main Methods:

  • Study included 220 hypercholesterolemic patients (50% women) with suspected Familial Hypercholesterolemia (FH).
  • Assessed Lp(a) concentrations, prevalence of CVD, coronary artery disease (CAD), and carotid atherosclerosis (plaques, intima-media thickness).

Main Results:

  • CVD and CAD were present in 24.5% and 21.4% of patients, respectively.
  • Higher Lp(a) levels were associated with CVD and CAD, with the association remaining significant for CAD after adjustments.
  • A high prevalence of elevated Lp(a) was observed (38.2% in moderate-to-high risk categories).
  • No significant association was found between Lp(a) levels and carotid plaques or intima-media thickness.

Conclusions:

  • Hypercholesterolemic patients exhibit a high prevalence of elevated Lp(a) levels.
  • Lp(a) risk categories are strongly associated with CAD, but not with carotid atherosclerosis.
Abstract

Keywords:
familial hypercholesterolemiaintima‐media thicknesslipoprotein(a)

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