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Cannabinoids: Adaptogens or Not?
Federico Karp1, Ignacio E León2,3
1Laboratorio de Nanobiomateriales, CINDEFI, Departamento de Química, Facultad de Ciencias Exactas, Universidad Nacional de La Plata and CONICET, La Plata, Argentina.
Cannabis and Cannabinoid Research
|May 7, 2025
Summary
This review compares cannabinoids (CNBs) and adaptogens, exploring their potential classification together. It examines their biological effects, stress resistance, and homeostasis capabilities for potential therapeutic overlap.
Area of Science:
- Pharmacology and Natural Product Chemistry
- Neurobiology and Physiology
- Integrative Medicine
Background:
- Humanity has historically sought natural substances to enhance stress resistance and homeostasis.
- Adaptogens and cannabinoids (CNBs) are natural compounds with potential therapeutic applications.
- The classification of CNBs alongside adaptogens remains a subject of scientific inquiry.
Purpose of the Study:
- To compare the biological effects of cannabinoids (CNBs) with adaptogens.
- To explore the scientific basis for potentially classifying CNBs as adaptogens.
- To analyze the properties of CNBs and adaptogens concerning stress resistance and homeostasis.
Main Methods:
- Review of adaptogen features: chemical structure, ligand-receptor interactions, and stress-coping mechanisms.
- Overview of preclinical and clinical studies on adaptogen effects against diverse stressors.
- Comprehensive review of CNBs' effects on the body and the endocannabinoid system.
Main Results:
- Adaptogens exhibit stress-resistance and homeostasis-enhancing properties.
- CNBs demonstrate a wide range of effects, with therapeutic potential for various diseases.
- The endocannabinoid system mediates many of the body-wide effects of CNBs.
Conclusions:
- Comparative analysis suggests potential overlap in biological effects between CNBs and adaptogens.
- Further research is needed to definitively classify cannabinoids within the adaptogen category.
- Understanding these properties could inform novel therapeutic strategies for stress-related conditions.
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