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Establishing the Minimal Clinically Important Difference for the Wisconsin Stone Quality of Life Questionnaire Using
Carl A Ceraolo1, David Song1, Victor Sandoval1
1Department of Urology, University of Rochester Medical Center, Rochester, New York, USA.
Journal of Endourology
|May 7, 2025
Summary
The Wisconsin Stone Quality of Life (WISQOL) questionnaire
Area of Science:
- Urology
- Health Outcomes Research
- Patient-Reported Outcomes
Background:
- The Wisconsin Stone Quality of Life (WISQOL) questionnaire assesses health-related quality of life in patients with kidney stone disease.
- Estimating the minimum clinically important difference (MCID) for WISQOL scores is crucial for interpreting patient outcomes.
- Previous studies have not established a definitive MCID threshold for the WISQOL tool.
Purpose of the Study:
- To determine the MCID threshold for the WISQOL questionnaire using both distribution- and anchor-based methods.
- To provide a benchmark for assessing meaningful changes in quality of life for kidney stone patients.
Main Methods:
- Retrospective analysis of 1197 patients from a single kidney stone clinic (January 2018 - November 2023).
- Collected WISQOL scores at initial and follow-up visits, alongside baseline characteristics.
- Employed distribution-based methods and anchor-based methods (cross-sectional, longitudinal within-group, and between-group) using global transition questions.
Main Results:
- Distribution-based MCID estimates ranged from 3.5 to 10.8.
- Anchor-based estimates varied: cross-sectional (3.1-13.6), within-group improvement (8.5-10.3), within-group deterioration (3.1-6.3), between-group improvement (9.1), and between-group deterioration (4.2).
- A conservative MCID threshold of 9 points for both improvement and deterioration in total WISQOL score was identified.
Conclusions:
- A change of 9 points in the WISQOL score represents a clinically significant difference for kidney stone patients.
- This established threshold can aid clinicians in interpreting WISQOL results for decision-making.
- The findings enhance the utility of the WISQOL questionnaire in clinical practice and research.
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