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Updated: May 12, 2025
Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
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N,N- and N,O-Bidentate-Chelation-Assisted Alkenyl C-H Functionalization
Yawei Zhang1, Chengxing Peng2, Xiaoli Li2
1School of Chemistry and Chemical Engineering, Qufu Normal University, Qufu 273165, China.
Abstract:
Chelation-assisted olefinic C-H functionalization has been demonstrated to be a powerful method of constructing multi-substituted alkenes from simpler ones. This strategy produces complex alkenes in a regio- and stereoselective manner, followed by C-H endo- and exo-cyclometallation. Among the various directing groups developed, N,N- and N,O-bidentate directing groups are the most widely used to selectively promote C-H functionalization due to their fine, tunable, and reversible coordination with the metal center. In this review, we discuss various N,N- and N,O-bidentate directing group-assisted olefinic C-H bond functionalization reactions, including alkenylation, alkylation, arylation, thiolation, silylation, halogenation, and cyclization.
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