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Dispersion-Driven Ligand Design for Cu(II)/Bis(oxazoline)-Catalyzed Asymmetric IEDDA Reactions

Feiyang Li1, Minjie Bi1, Lixin Cui1

  • 1Key Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, Zhejiang Key Laboratory of Organosilicon Material Technology, College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, 2318 Yuhangtang Road, Hangzhou 311121, Zhejiang, China.

Organic Letters
|December 23, 2025
PubMed
Summary

This study introduces a new ligand strategy for asymmetric catalysis, leveraging London dispersion interactions to improve both efficiency and stereoselectivity in a key chemical reaction. The findings highlight dispersion forces as a crucial element for designing advanced catalytic systems.

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