[Basis for the use of enclosed 125I sources for interstitial radiation therapy]

Experimental models of closed sources of 125I low energy photon radiation in the titanium capsules sealed by means of pulsed laser welding were designed. Doses in the tissue equivalent medium from a single 125I point source were calculated using ES-1022 computer, tables for calculating dose fields in different layouts of sources were drawn, and layout parameters in preset doses calculated. Using the 125I source in interstitial irradiation of murine breast tumors one managed to establish the local nature of tissues corresponding to the calculated dose distribution for photon radiation with the energy of 27-35 keV.