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EXERT-BCN: An Exercise Regimen Designed to Improve Body Composition, Functional Capacity, and Strength After
David J Carpenter1, Chris Peluso2, Christie Hilton3
1Department of Radiation Oncology, WellStar Paulding Medical Center, Hiram, GA.
JCO Oncology Practice
|May 7, 2025
Summary
This study shows that a 3-month nutrition and high-intensity resistance training program significantly improved body composition, muscle mass, and functional capacity in women with breast cancer. Quality of life also saw notable improvements.
Area of Science:
- Exercise Oncology
- Cancer Rehabilitation
- Metabolic Health
Background:
- Effective strategies for improving body composition and metabolic health are crucial for breast cancer patient care.
- Cancer treatments can lead to significant body composition changes and metabolic dysregulation.
Purpose of the Study:
- To investigate the impact of a nutrition regimen focused on food quality combined with high-load resistance training on body composition and functional capacity in women with breast cancer.
- To assess improvements in metabolic/hormonal dysregulation, functional mobility, balance, activity levels, and quality of life.
Main Methods:
- Forty-four women with breast cancer (survivors on therapy or surveillance, excluding chemotherapy) participated.
- A dose-escalated, high-load resistance training program was implemented in an exercise oncology facility.
- Participants received nutrition counseling focused on food quality and adequate protein intake, with discussions integrated into exercise sessions and bi-monthly meetings.
Main Results:
- Significant increases in strength (36.5% in composite load lifted) and balance (18% in Y-balance scores) were observed.
- Body fat decreased by 6.6% (1.8 kg), while muscle mass increased by 1.4% (0.5 kg).
- Resting metabolic rate increased by 0.8%, and all quality-of-life measures showed significant improvements.
Conclusions:
- A 3-month intervention combining nutrition counseling and high-intensity resistance training effectively improved body composition, increasing muscle mass and reducing adipose tissue.
- The regimen led to significant gains in strength, mobility, and functional status.
- Patient-reported quality of life significantly improved across multiple validated questionnaires.
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