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Area of Science:

  • Infectious Diseases
  • Mycology
  • Urology

Background:

  • Catheter-associated urinary tract infections (CAUTIs) are a major healthcare concern, predominantly caused by bacteria.
  • Candida auris, a fungus, is increasingly identified as a urinary pathogen, posing a growing threat due to its resistance and high mortality.
  • Significant knowledge gaps exist regarding the prevalence and pathogenesis of Candida auris in urinary tract infections.

Purpose of the Study:

  • To investigate the prevalence of Candida auris in urine samples.
  • To analyze the association of Candida auris urine isolates with urinary catheters.
  • To assess the clinical significance and resistance patterns of Candida auris in urinary tract infections.

Main Methods:

  • Analysis of 12,996 clinical strains of Candida auris.
  • Examination of isolation sources, focusing on urine and urinary catheters.
  • Review of anecdotal data on mortality rates and antifungal resistance.

Main Results:

  • Urine is the second most common source of Candida auris isolation in the United States and third globally.
  • Candida auris urine isolates are frequently associated with urinary catheters.
  • Early evidence suggests the development of echinocandin resistance in urinary Candida auris isolates, alongside high mortality rates.

Conclusions:

  • Candida auris is a significant and increasing cause of urinary tract infections.
  • Urinary tract infections caused by Candida auris are associated with urinary catheters and poor outcomes.
  • Further research into Candida auris urinary tract infection pathogenesis and resistance is essential for effective management.